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  1. Article

    Open Access

    NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair

    The transcription factor nuclear factor κB (NF-κB)/p65 is the master regulator of inflammation in Duchenne muscular dystrophy (DMD). Disease severity is reduced by NF-κB inhibition in the mdx mouse, a murine DMD ...

    J D Proto, Y Tang, A Lu, W C W Chen, E Stahl, M Poddar, S A Beckman… in Cell Death & Disease (2015)

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  2. No Access

    Article

    Expression of IL-2 in β cells by AAV8 gene transfer in pre-diabetic NOD mice prevents diabetes through activation of FoxP3-positive regulatory T cells

    We previously demonstrated that intraperitoneal delivery of adeno-associated virus serotype 8 (AAV8) stably transduces the pancreas, including the β cells in the pancreatic islets. We further demonstrated the ...

    R R Flores, L Zhou, P D Robbins in Gene Therapy (2014)

  3. No Access

    Article

    LIM domain protein-3 (LMP3) cooperates with BMP7 to promote tissue regeneration by ligament progenitor cells

    Gene transfer of key regulators of osteogenesis for mesenchymal stem cells represents a promising strategy to regenerate bone. It has been reported that LMP3, a transcription variant of LIM domain mineralizati...

    Z Lin, H F Rios, C-H Park, A D Taut, Q **, J V Sugai, P D Robbins… in Gene Therapy (2013)

  4. No Access

    Article

    dsAAV8-mediated gene transfer and β-cell expression of IL-4 and β-cell growth factors are capable of reversing early-onset diabetes in NOD mice

    Type-I diabetes is a chronic disease mediated by autoimmune destruction of insulin-producing β-cells. Although progress has been made towards improving diabetes-associated pathologies and the quality of life f...

    D F Gaddy, M J Riedel, S Bertera, T J Kieffer, P D Robbins in Gene Therapy (2012)

  5. No Access

    Article

    The antitumor effects of adenoviral-mediated, intratumoral delivery of interleukin 23 require endogenous IL-12

    Interleukin (IL)-23 is a member of the IL-12 family of heterodimeric cytokines, comprised of p19 and p40 subunits, which exhibits immunostimulatory properties similar to IL-12. We have demonstrated previously ...

    J Reay, A Gambotto, P D Robbins in Cancer Gene Therapy (2012)

  6. No Access

    Article

    Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice

    The IκB kinase (IKKα, β and the regulatory subunit IKKγ) complex regulates nuclear factor of κB (NF-κB) transcriptional activity, which is upregulated in many chronic inflammatory diseases. NF-κB signaling pro...

    Y Tang, D P Reay, M N Salay, M Y Mi, P R Clemens, D C Guttridge… in Gene Therapy (2010)

  7. No Access

    Article

    DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes

    Glucagon-like peptide-1 (GLP-1) is an incretin hormone that performs a wide array of well-characterized antidiabetic actions, including stimulation of glucose-dependent insulin secretion, upregulation of insul...

    M J Riedel, D F Gaddy, A Asadi, P D Robbins, T J Kieffer in Gene Therapy (2010)

  8. No Access

    Article

    Adenoviral-mediated, intratumor gene transfer of interleukin 23 induces a therapeutic antitumor response

    Interleukin 23 (IL-23) is a member of the IL-12 family of heterodimeric cytokines, composed of p19 and p40 subunits, which exhibits immunostimulatory properties similar to IL-12. IL-23 has been shown to posses...

    J Reay, S-H Kim, E Lockhart, J Kolls, P D Robbins in Cancer Gene Therapy (2009)

  9. No Access

    Article

    Progress and Prospects: genetic treatments for disorders of bones and joints

    Gene therapies directed toward the treatment of arthritis and tissue repair continue to be the most active areas of research for bone and joint diseases. In the past 2 years, two trials in rheumatoid arthritis...

    C H Evans, S C Ghivizzani, P D Robbins in Gene Therapy (2009)

  10. No Access

    Article

    Ex vivo-transduced autologous skin fibroblasts expressing human Lim mineralization protein-3 efficiently form new bone in animal models

    Local gene transfer of the human Lim mineralization protein (LMP), a novel intracellular positive regulator of the osteoblast differentiation program, can induce efficient bone formation in rodents. To develop...

    W Lattanzi, C Parrilla, A Fetoni, G Logroscino, G Straface, G Pecorini… in Gene Therapy (2008)

  11. No Access

    Article

    Small molecules in stem cell self-renewal and differentiation

    The use of stem cells in regenerative medicine is a promising approach to the treatment of disease and injury. Natural and synthetic small molecules have been shown to be useful chemical tools for controlling ...

    R C Schugar, P D Robbins, B M Deasy in Gene Therapy (2008)

  12. No Access

    Article

    Targeting of products of genes to tumor sites using adoptively transferred A-NK and T-LAK cells

    Despite successes in animals, cytokine gene expression selectively in human tumors is difficult to achieve owing to lack of efficient delivery methods. Since interleukin (IL)-2-activated natural killer (A-NK) ...

    S Goding, Q Yang, Z Mi, P D Robbins, P H Basse in Cancer Gene Therapy (2007)

  13. No Access

    Article

    Effect of BMP-2 gene transfer on bone healing in sheep

    Critical size defects of bone and delayed fracture healing due to metabolic disorders are still problems in orthopaedic surgery. Adenoviral vectors encoding bone morphogenetic protein-2 (Ad.BMP-2) have been us...

    M Egermann, C A Lill, K Griesbeck, C H Evans, P D Robbins, E Schneider… in Gene Therapy (2006)

  14. No Access

    Article

    Direct adenovirus-mediated IGF-I gene transduction of synovium induces persisting synovial fluid IGF-I ligand elevations

    Insulin-like growth factor-I (IGF-I) is one of the most influential growth factors in cartilage repair. Maintenance of adequate IGF-I levels after articular repair procedures is complicated by the short biolog...

    L R Goodrich, B D Brower-Toland, L Warnick, P D Robbins, C H Evans… in Gene Therapy (2006)

  15. No Access

    Article

    Cancer gene therapy using a novel secretable trimeric TRAIL

    Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF family, is a type II transmembrane cytokine molecule. Soluble TRAIL has been shown to induce apoptosis in a wide varie...

    C-Y Kim, M Jeong, H Mushiake, B-M Kim, W-B Kim, J P Ko, M-H Kim, M Kim… in Gene Therapy (2006)

  16. No Access

    Article

    Efficient gene delivery to human and rodent islets with double-stranded (ds) AAV-based vectors

    Transplantation of allogeneic pancreatic islets is an effective approach to treat type 1 diabetes. To bypass the need for systemic administration of immunosuppression drugs following transplantation, approache...

    K K Rehman, Z Wang, R Bottino, A N Balamurugan, M Trucco, J Li, X **ao… in Gene Therapy (2005)

  17. No Access

    Article

    Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy

    Combination of growth factor gene-enhanced cartilage matrix synthesis with interleukin-1 receptor antagonist protein (IL-1Ra) abrogation of cartilage matrix degradation may reduce and possibly reverse cartilag...

    A J Nixon, J L Haupt, D D Frisbie, S S Morisset, C W McIlwraith… in Gene Therapy (2005)

  18. No Access

    Article

    Efficient bone formation by gene transfer of human LIM mineralization protein-3

    LIM mineralization protein (LMP) is a novel positive regulator of the osteoblast differentiation program. In humans, three different LMP splice variants have been identified: LMP-1, LMP-2, and LMP-3. Gene tran...

    E Pola, W Gao, Y Zhou, R Pola, W Lattanzi, C Sfeir, A Gambotto, P D Robbins in Gene Therapy (2004)

  19. No Access

    Article

    The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immunizing antigen

    We have demonstrated previously that local, adenoviral-mediated gene transfer of vIL-10 to a single joint of rabbits and mice with experimental arthritis can suppress disease in both the treated and untreated ...

    E R Lechman, A Keravala, J Nash, S-H Kim, Z Mi, P D Robbins in Gene Therapy (2003)

  20. No Access

    Article

    Human adenovirus type 35: nucleotide sequence and vector development

    In this report, we describe the complete 34 794 base pair genomic sequence of the human adenovirus serotype 35 (Ad35) Holden strain. The viral genome exhibits a compact organization similar to other adenoviral...

    W Gao, P D Robbins, A Gambotto in Gene Therapy (2003)

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