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  1. No Access

    Article

    Test-suite-guided discovery of least privilege for cloud infrastructure as code

    Infrastructure as code (IaC) for the cloud, which automatically configures a system’s cloud environment from source code, is an important practice thanks to its efficient, reproducible provisioning. On a cloud...

    Ryo Shimizu, Yuna Nunomura, Hideyuki Kanuka in Automated Software Engineering (2024)

  2. Article

    Open Access

    Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

    Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence of XBB.1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB.1.5 evolved from XBB.1 by acquiring the S486P spike (S) mu...

    Tomokazu Tamura, Takashi Irie, Sayaka Deguchi, Hisano Yajima in Nature Communications (2024)

  3. No Access

    Article

    Intrahepatic cholangiocarcinoma with FGFR2 fusion gene positive that responded to pemigatinib and caused hypophosphatemia

    Intrahepatic cholangiocarcinoma is a condition with a poor prognosis. Traditionally, there was no cure unless important drugs such as gemcitabine, cisplatin, and tegafur/gimeracil/uracil potassium showed effic...

    Yoshinori Kikuchi, Kazuhisa Yamaguchi in International Cancer Conference Journal (2023)

  4. No Access

    Article

    IgA nephropathy diagnosed as a result of acute exacerbation due to G-CSF administration

    Granulocyte colony-stimulating factor (G-CSF) is commonly used to stimulate bone marrow production. G-CSF is usually safe but sometimes causes serious adverse effects and, in rare cases, exacerbates glomerulon...

    Keita Hattori, Ryo Shimizu, Shoichiro Tanaka, Takashi Terashima in CEN Case Reports (2023)

  5. Article

    Open Access

    Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

    In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two...

    Tomokazu Tamura, Jumpei Ito, Keiya Uriu, Jiri Zahradnik in Nature Communications (2023)

  6. No Access

    Chapter and Conference Paper

    Feature-Based Cloud Provisioning for Rehosting

    As IT infrastructure is increasingly rehosted to public clouds, IT system development must become more efficient. Traditionally, configuring and provisioning cloud services to meet the same requirements as on-...

    Misaki Mito, Takatoshi Ohara, Ryo Shimizu in Knowledge-Based Software Engineering: 2022 (2023)

  7. No Access

    Article

    A case of juvenile-onset fibrillary glomerulonephritis diagnosed by mass spectrometry and immunohistochemistry of DNAJB9

    Fibrillary glomerulonephritis (FGN) is a rare glomerular disease. FGN is characterized by the deposition of randomly arranged, nonbranching microfibrils in the mesangium and glomerular basement membrane. The d...

    Keita Hattori, Ryo Shimizu, Shoichiro Tanaka, Takashi Terashima in CEN Case Reports (2022)

  8. Article

    Open Access

    Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

    The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern1. In this study, our statistical modelling suggests that Omicron has spread more rapidly than the Delta variant in several cou...

    Rigel Suzuki, Daichi Yamasoba, Izumi Kimura, Lei Wang, Mai Kishimoto, Jumpei Ito in Nature (2022)

  9. Article

    Open Access

    Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

    During the current coronavirus disease 2019 (COVID-19) pandemic, a variety of mutations have accumulated in the viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and, at the time of ...

    Akatsuki Saito, Takashi Irie, Rigel Suzuki, Tadashi Maemura, Hesham Nasser in Nature (2022)

  10. No Access

    Article

    An older age, a longer duration between injury and surgery, and positive pivot shift test results increase the prevalence of articular cartilage injury during ACL reconstruction in all three compartments of the knee in patients with ACL injuries

    To investigate factors that influence the prevalence of articular cartilage injury in patients with anterior cruciate ligament (ACL) injury.

    Atsuo Nakamae, Ayato Miyamoto, Goki Kamei in Knee Surgery, Sports Traumatology, Arthros… (2022)

  11. No Access

    Article

    Clinicopathological characteristics of colorectal metastases from lung cancer: systematic review of the case reports in the Japanese literature

    Since colorectal metastases from primary lung cancer are rare, the location of metastatic lesion and prognostic factors have not been well evaluated. Therefore, we carried out a systematic review and meta-anal...

    Yoshinori Kikuchi, Hideaki Shimada in International Cancer Conference Journal (2021)

  12. No Access

    Article

    Migration of a pancreatic duct stent into the peritoneal cavity during chemotherapy for pancreatic malignant lymphoma

    A 68-year-old man with epigastric pain was admitted for acute pancreatitis and obstructive jaundice caused by Primary pancreatic malignant lymphoma. Computed tomography showed diffuse enlargement of the whole ...

    Shinya Taki, Takao Maekita, Ryo Shimizu in Clinical Journal of Gastroenterology (2021)

  13. Article

    Open Access

    Prognostic value of 18F-fluorodeoxyglucose positron emission tomography in patients with small hepatocellular carcinoma treated by radiofrequency ablation

    18F-fluorodeoxyglucose (18F-FDG) uptake in hepatocellular carcinoma (HCC) is significantly associated with early recurrence and survival after curative surgical resection. However, there are no reports regarding ...

    Yoshiyuki Ida, Hideyuki Tamai, Naoki Shingaki, Ryo Shimizu in Cancer Imaging (2020)

  14. No Access

    Article

    Endoscopic ultrasound-guided radiofrequency ablation of porcine liver

    Animal studies of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) of the liver have rarely been reported. We assessed the effectiveness and safety of EUS-RFA in pigs.

    Shuya Maeshima, Yoshiyuki Ida, Ryo Shimizu, Yuki Kawaji in Journal of Medical Ultrasonics (2020)

  15. No Access

    Article

    Efficacy and safety of oral deferasirox treatment for transfusional iron overload in pure red cell aplasia patients after allogeneic stem cell transplantation

    Ryo Shimizu, Masahiro Takeuchi, Emiko Sakaida, Chikako Ohwada in Annals of Hematology (2019)

  16. No Access

    Article

    Characteristics and prognosis of patients with non-immunoglobulin-M monoclonal gammopathy of undetermined significance: a retrospective study

    Non-immunoglobulin (Ig)-M monoclonal gammopathy of undetermined significance (MGUS) is a precursor lesion with the potential to evolve into a malignant plasma cell neoplasm. The prevalence of MGUS differs by e...

    chihiro Kuwabara, Yukie Sakuma, Ayaka Kume in International Journal of Hematology (2019)

  17. No Access

    Article

    Electrochemiluminescence and voltammetry of tris(2,2′-bipyridine)ruthenium (II) with amphetamine-type stimulants as coreactants: an application to the discrimination of methamphetamine

    We have tried to establish an electrochemical detection method for screening of the stimulants in the forensic samples using electrochemiluminescence (ECL) and voltammetric techniques.

    Fumiki Takahashi, Saki Nitta, Ryo Shimizu, Jiye ** in Forensic Toxicology (2018)

  18. Article

    Open Access

    Evaluation of sorafenib for advanced hepatocellular carcinoma with low α-fetoprotein in arrival time parametric imaging using contrast-enhanced ultrasonography

    To determine the usefulness of arrival time parametric imaging (AtPI) using contrast-enhanced ultrasonography (CEUS) with Sonazoid in evaluating early response to sorafenib for hepatocellular carcinoma (HCC).

    Kazue Shiozawa, Manabu Watanabe, Takashi Ikehara in Journal of Medical Ultrasonics (2017)

  19. Article

    Open Access

    Differences in joint morphology between the knee and ankle affect the repair of osteochondral defects in a rabbit model

    Although differences in the results of the bone marrow stimulation technique between the knee and ankle have been reported, a detailed mechanism for those differences has not been clarified. The purpose of thi...

    Manami Makitsubo, Nobuo Adachi in Journal of Orthopaedic Surgery and Research (2016)

  20. No Access

    Article

    The arterial tumor enhancement pattern on contrast-enhanced computed tomography is associated with primary cancer death after radiofrequency ablation for small hepatocellular carcinoma

    Critical recurrences after radiofrequency ablation for hepatocellular carcinoma (HCC), such as intrahepatic metastases or dissemination, and extrahepatic metastases or seeding, which are difficult to treat rad...

    Ryo Shimizu, Hideyuki Tamai, Yoshiyuki Mori, Naoki Shingaki in Hepatology International (2016)

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