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Article
Open AccessComparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5
The unremitting emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants necessitates ongoing control measures. Given its rapid spread, the new Omicron subvariant BA.5 requires urgent...
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Article
Open AccessAttenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant
The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern1. In this study, our statistical modelling suggests that Omicron has spread more rapidly than the Delta variant in several cou...
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Article
Open AccessAltered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein2. Here we show that the spike protein of Omicron has a higher affinity for ACE2 compared with Delta, and a mark...
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Article
Open AccessEnhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation
During the current coronavirus disease 2019 (COVID-19) pandemic, a variety of mutations have accumulated in the viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and, at the time of ...
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Article
Open AccessNew World feline APOBEC3 potently controls inter-genus lentiviral transmission
The apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3; A3) gene family appears only in mammalian genomes. Some A3 proteins can be incorporated into progeny virions and inhibit lentivir...
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Article
Role of magnetic resonance imaging for evaluation of tumors in the cardiac region
The aim of this study was to review the role of MRI in the assessment of heart neoplasm, 25 cases with heart neoplasm (10 myxoma, 6 rhabdomyoma, 5 angiosarcoma, 2 mesothelioma, 1 lymphoma, and 1 fibroma) were ...
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Chapter
Validating the Utility of Abstraction Techniques
A number of recent research efforts have been based on the hypothesis that encapsulation techniques, formal specification, and verification lead to significant improvements in program quality. As we gain exper...
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Chapter
(Preliminary) An Informal Definition of Alphard
The Alphard language was designed to support the joint goals of facilitating contemporary programming methodology, encouraging formal specification of programs and verification of those specifications, allowin...
