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Article
Sensitivity and specificity of the uniform field electroretinogram in glaucoma detection in comparison to the pattern electroretinogram
To determine the ability of the photopic negative response (PhNR) of the uniform field electroretinogram (UF-ERG) to identify early glaucomatous changes in comparison to the checkerboard and bar stimuli of the...
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Article
Open AccessIndirect Comparison of Lenadogene Nolparvovec Gene Therapy Versus Natural History in Patients with Leber Hereditary Optic Neuropathy Carrying the m.11778G>A MT-ND4 Mutation
Lenadogene nolparvovec is a promising novel gene therapy for patients with Leber hereditary optic neuropathy (LHON) carrying the m.11778G>A ND4 mutation (MT-ND4). A previous pooled analysis of phase 3 studies sho...
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Article
Pathophysiology of central serous chorioretinopathy: a literature review with quality assessment
The pathogenesis of central serous chorioretinopathy (CSCR), a pachychoroid disease, is poorly understood. While choroid hyperpermeability and retinal pigment epithelium dysfunction are cornerstones for develo...
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Article
Open AccessNatural history of patients with Leber hereditary optic neuropathy—results from the REALITY study
REALITY is an international observational retrospective registry of LHON patients evaluating the visual course and outcome in Leber hereditary optic neuropathy (LHON).
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Reference Work Entry In depth
Optic Atrophy and Papilledema
Optic atrophy is a misnomer. Although the term atrophy generally refers to physiologic involution or reduction in size, optic atrophy refers to cell death. In particular, optic atrophy represents the permanent...
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Reference Work Entry In depth
Hereditary Optic Neuropathies
The hereditary optic neuropathies consist of a group of disorders in which optic nerve dysfunction is either isolated or part of a systemic disease, and direct inheritance is clinically or genetically proven. ...
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Article
Photopic negative response using a handheld mini-ganzfeld stimulator in healthy adults: normative values, intra- and inter-session variability
To determine normative values, intra- and inter-session variability for a range of parameters derived from the photopic negative response (PhNR) using a handheld mini-Ganzfeld stimulator in healthy normal adults.
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Article
Open AccessRetinal ganglion cell dysfunction in preclinical Alzheimer’s disease: an electrophysiologic biomarker signature
The current study evaluated retinal function using electroretinography (ERG) in cognitively healthy (CH) participants with preclinical Alzheimer’s disease (AD), as classified by cerebral spinal fluid (CSF) Aβ42/T...
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Living Reference Work Entry In depth
Hereditary Optic Neuropathies
The hereditary optic neuropathies consist of a group of disorders in which optic nerve dysfunction is either isolated or part of a systemic disease, and direct inheritance is clinically or genetically proven. ...
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Living Reference Work Entry In depth
Optic Atrophy and Papilledema
Optic atrophy is a misnomer. Although the term atrophy generally refers to physiologic involution or reduction in size, optic atrophy refers to cell death. In particular, optic atrophy represents the permanent...
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Article
Pathophysiology of Conversion to Symptomatic Leber Hereditary Optic Neuropathy and Therapeutic Implications: a Review
Leber’s hereditary optic neuropathy (LHON) is a genetic disease of the mitochondrial genome that mainly affects the retinal ganglion cells (RGC) of the inner retina resulting in central vision loss. New unders...
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Article
A method for identifying color vision deficiency malingering
To propose a new test to identify color vision deficiency malingering.