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Article
Applying the 2022 optic neuritis criteria to noninflammatory optic neuropathies with optic nerve T2-hyperintensity: an observational study
Recent diagnostic criteria for optic neuritis include T2-hyperintensity of the optic nerve (ON), even without associated contrast enhancement. However, isolated ON-T2-hyperintensity is a nonspecific finding fo...
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Article
Glaucoma as a cause of optic nerve abnormalities on magnetic resonance imaging
To report a series of patients with glaucoma and optic nerve abnormalities on magnetic resonance imaging (MRI) in at least one-eye, and to determine whether these findings correlate with the severity of glaucoma.
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Article
Clinical trials for idiopathic intracranial hypertension: what are we treating?
New guidelines for designing controlled clinical trials for idiopathic intracranial hypertension (IIH) have been published. The design of such trials remains a challenge, as the heterogeneity of IIH necessitat...
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Article
The expanding spectrum of idiopathic intracranial hypertension
Once considered a rare and often difficult diagnosis in the era predating routine MRI, idiopathic intracranial hypertension has become an everyday concern in ophthalmology and neurology clinics where, especial...
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Article
Open AccessIndirect Comparison of Lenadogene Nolparvovec Gene Therapy Versus Natural History in Patients with Leber Hereditary Optic Neuropathy Carrying the m.11778G>A MT-ND4 Mutation
Lenadogene nolparvovec is a promising novel gene therapy for patients with Leber hereditary optic neuropathy (LHON) carrying the m.11778G>A ND4 mutation (MT-ND4). A previous pooled analysis of phase 3 studies sho...
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Article
Open AccessDevelopments in the Treatment of Leber Hereditary Optic Neuropathy
To outline the current landscape of treatments for Leber hereditary optic neuropathy (LHON) along the therapeutic delivery pipeline, exploring the mechanisms of action and evidence for these therapeutic approa...
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Article
Open AccessAbsence of lenadogene nolparvovec DNA in a brain tumor biopsy from a patient in the REVERSE clinical study, a case report
Leber Hereditary Optic Neuropathy (LHON) is a rare, maternally-inherited mitochondrial disease that primarily affects retinal ganglion cells (RGCs) and their axons in the optic nerve, leading to irreversible, ...
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Article
Open AccessNatural history of patients with Leber hereditary optic neuropathy—results from the REALITY study
REALITY is an international observational retrospective registry of LHON patients evaluating the visual course and outcome in Leber hereditary optic neuropathy (LHON).
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Reference Work Entry In depth
Hereditary Optic Neuropathies
The hereditary optic neuropathies consist of a group of disorders in which optic nerve dysfunction is either isolated or part of a systemic disease, and direct inheritance is clinically or genetically proven. ...
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Reference Work Entry In depth
Third-, Fourth-, and Sixth-Nerve Lesions and the Cavernous Sinus
The unique anatomy of the third, fourth, and sixth cranial nerves and the cavernous sinus makes them susceptible to a host of diseases and conditions that impair ocular motor function.
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Article
Vision-related quality-of-life in pediatric primary brain tumor patients
Brain tumors are the leading cause of death from childhood cancer. Although overall survival has improved due to earlier detection, better therapies, and improved surveillance, visual dysfunction and impaired ...
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Chapter
Correction to: Acute Visual Loss
Chapter 5 in: K. L. Roos (ed.), Emergency Neurology, https://doi.org/10.1007/978-3-030-75778-6_5
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Living Reference Work Entry In depth
Hereditary Optic Neuropathies
The hereditary optic neuropathies consist of a group of disorders in which optic nerve dysfunction is either isolated or part of a systemic disease, and direct inheritance is clinically or genetically proven. ...
-
Living Reference Work Entry In depth
Third-, Fourth-, and Sixth-Nerve Lesions and the Cavernous Sinus
The unique anatomy of the third, fourth, and sixth cranial nerves and the cavernous sinus makes them susceptible to a host of diseases and conditions that impair ocular motor function.
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Chapter
Acute Visual Loss
Visual loss is a common symptom in neurologic emergencies. Although ocular causes of visual loss are usually identified by eye care specialists, many patients appear in the emergency department or a neurologis...
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Chapter
Push Me Pull You
This is a case of an 80-year-old woman who was referred for neuro-ophthalmologic assessment because of 11 months of disc swelling and progressive vision loss in the left eye.
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Chapter
Treatment of Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in older individuals and usually occurs in patients with vascular risk factors and a “disc at risk” (i.e., a s...
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Chapter
Treatment of Central Retinal Artery Occlusion
Central retinal artery occlusion (CRAO) is the ocular equivalent of an acute cerebral ischemic event. It is most commonly caused by an embolus from the ipsilateral carotid artery, aortic arch or heart, leading...
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Chapter
Acute Visual Disturbances
The visual pathways traverse more than one-third of the brain, explaining why visual function is frequently affected by intracranial lesions and a wide range of neurological disorders. Visual disturbances such...
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Article
Optical coherence tomography retinal ganglion cell complex analysis for the detection of early chiasmal compression
To report patients with sellar tumors and chiasmal compression with normal visual fields, who demonstrate damage to the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) on optical coherence tom...