15 Result(s)
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Article
Multi-omics portrait of ductal carcinoma in situ in young women
Young patients with breast ductal carcinoma in situ (DCIS) often face a poorer prognosis. The genomic intricacies in young-onset DCIS, however, remain underexplored.
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Article
Analysis of the influential factors of the emotional health of patients with cancer based on the structural equation model: the role of social media and emotional support
To explore the mental health status of patients with cancer and related influential factors and provide a scientific basis to reduce serious emotional problems, improve the quality of life of cancer survivors ...
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Article
Open AccessThe interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms
N6-methyladenosine(m6A) is one of the most abundant modifications of mammalian cellular RNAs. m6A regulates various biological functions in epitranscriptomic ways, including RNA stability, decay, splicing, transl...
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Long-term survival after sentinel lymph node biopsy or axillary lymph node dissection in pN0 breast cancer patients: a population-based study
Findings from randomized clinical trials have shown that survival in patients with sentinel lymph node (SLN)-negative breast cancer is noninferior with SLN biopsy (SLNB) alone versus further axillary lymph nod...
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Article
Efficacy and steroid-sparing effect of tacrolimus in patients with autoimmune cytopenia
The aim of this study was to evaluate the efficacy, safety, and steroid-sparing effect of tacrolimus in patients with autoimmune cytopenia, including immune thrombocytopenia (ITP), autoimmune hemolytic anemia ...
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Article
The Role of Sentinel Lymph Node Map** in High-grade Endometrial Cancer
Total hysterectomy with lymph node assessment is the current standard-of-care for surgical staging in apparent early-stage endometrial cancer. Compared to the traditional complete pelvic lymphadenectomy with o...
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Article
Open AccessNail pigmentation induced by chemotherapy: an observational study of patients with early-stage breast cancer
Chemotherapy-induced nail pigmentation is a common adverse effect, but prospective studies focussing on its onset, recovery, and severity are few. We aim to evaluate the pattern of chemotherapy-induced nail pi...
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Open AccessRetro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma
Glioblastoma (GBM), one of the most common primary intracranial malignant tumours, is very difficult to be completely excised by surgery due to its irregular shape. Here, we use an MRI/NIR fluorescence dual-mo...
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Article
Open AccessThe STING1 network regulates autophagy and cell death
Cell death and immune response are at the core of life. In past decades, the endoplasmic reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a fundamental role in the production of...
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Article
Open AccessCPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4
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Article
Open AccessSystemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma
Gene-modified autologous T cells expressing NY-ESO-1c259, an affinity-enhanced T-cell receptor (TCR) reactive against the NY-ESO-1-specific HLA-A*02-restricted peptide SLLMWITQC (NY-ESO-1 SPEAR T-cells; GSK 794),...
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Article
Pretreatment anti-Mullerian hormone-based nomogram predicts menstruation status after chemotherapy for premenopausal women with hormone receptor-positive early breast cancer
Ovarian function is important for optimizing endocrine treatment in patients with hormone receptor-positive (HR+) early breast cancer (eBC). The aim of the study was to determine whether patients’ pretreatment...
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Article
Diagnostic Accuracy of Bronchodilator Response for Asthma in a Population of South China
A significant bronchodilator response is commonly defined as a 12% or greater and 200 ml or greater change in FEV1 from baseline according to the 2005 American Thoracic Society (ATS)/European Respiratory Society ...
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Article
Prognostic value of endocrine treatment-related symptoms in patients with breast cancer: a meta-analysis
Endocrine therapy is associated with improved disease-free survival (DFS) in hormone receptor-positive breast cancer, but it is also associated with many adverse events. The aim of this study was to clarify t...
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Article
Leptomeningeal metastasis from solid tumors: a single center experience in Chinese patients
Leptomeningeal metastasis (LM) is a devastating complication of solid tumors. A retrospective study was carried out to evaluate the outcome and prognostic factors of LM. Patients with LM were identified throug...
