386 Result(s)
within
Rui-** **ao
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAsymmetric total synthesis of polycyclic xanthenes and discovery of a WalK activator active against MRSA
The development of new antibiotics continues to pose challenges, particularly considering the growing threat of multidrug-resistant Staphylococcus aureus. Structurally diverse natural products provide a promising...
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Open AccessHarnessing virus flexibility to selectively capture and profile rare circulating target cells for precise cancer subty**
The effective isolation of rare target cells, such as circulating tumor cells, from whole blood is still challenging due to the lack of a capturing surface with strong target-binding affinity and non-target-ce...
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Open AccessOrganic fertilization co-selects genetically linked antibiotic and metal(loid) resistance genes in global soil microbiome
Antibiotic resistance genes (ARGs) and metal(loid) resistance genes (MRGs) coexist in organic fertilized agroecosystems based on their correlations in abundance, yet evidence for the genetic linkage of ARG-MRG...
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Open AccessThe role of CO2 in the genesis of Dabie-type porphyry molybdenum deposits
Porphyry-type molybdenum deposits, many of which are in China, supply most of the World’s molybdenum. Of particular importance are the molybdenum deposits located in the Qinling-Dabie region that are responsib...
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Open AccessReal-time predictive model of extrauterine growth retardation in preterm infants with gestational age less than 32 weeks
The aim of this study was to develop a real-time risk prediction model for extrauterine growth retardation (EUGR). A total of 2514 very preterm infants were allocated into a training set and an external valida...
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Open AccessCrocin's role in modulating MMP2/TIMP1 and mitigating hypoxia-induced pulmonary hypertension in mice
To explore the molecular pathogenesis of pulmonary arterial hypertension (PAH) and identify potential therapeutic targets, we performed transcriptome sequencing of lung tissue from mice with hypoxia-induced pu...
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Open AccessDrug screening on digital microfluidics for cancer precision medicine
Drug screening based on in-vitro primary tumor cell culture has demonstrated potential in personalized cancer diagnosis. However, the limited number of tumor cells, especially from patients with early stage ca...
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Open AccessInverted device architecture for high efficiency single-layer organic light-emitting diodes with imbalanced charge transport
Many wide-gap organic semiconductors exhibit imbalanced electron and hole transport, therefore efficient organic light-emitting diodes require a multilayer architecture of electron- and hole-transport material...
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Open AccessBiosynthetic production of anticoagulant heparin polysaccharides through metabolic and sulfotransferases engineering strategies
Heparin is an important anticoagulant drug, and microbial heparin biosynthesis is a potential alternative to animal-derived heparin production. However, effectively using heparin synthesis enzymes faces challe...
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Open AccessPan-cancer analysis reveals correlation between RAB3B expression and tumor heterogeneity, immune microenvironment, and prognosis in multiple cancers
RAB3B is essential for the transportation and secretion within cells. Its increased expression is linked to the development and progression of various malignancies. However, understanding of RAB3B’s involvemen...
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Open AccessInvestigation of the correlation between platelet antibodies and peripheral blood cytopenia in patients with hepatocellular carcinoma
The primary triggers that stimulate the body to generate platelet antibodies via immune mechanisms encompass events such as pregnancy, transplantation, and blood transfusion. Interestingly, our findings reveal...
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Open AccessAuthor Correction: Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
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Open AccessEffect of hydroxychloroquine blood concentration on the efficacy and ocular toxicity of systemic lupus erythematosus
In the absence of evidence-based guidance on the impact of hydroxychloroquine (HCQ) blood concentration on efficacy and ocular toxicity in systemic lupus erythematosus (SLE), the clinical monitoring of HCQ blo...
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Open AccessNADPH oxidase 2 mediates cardiac sympathetic denervation and myocyte autophagy, resulting in cardiac atrophy and dysfunction in doxorubicin-induced cardiomyopathy
Doxorubicin has been used extensively as a potent anticancer agent, but its clinical use is limited by its cardiotoxicity. However, the underlying mechanisms remain to be fully elucidated. In this study, we te...
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Open AccessDislocation Majorana bound states in iron-based superconductors
We show that lattice dislocations of topological iron-based superconductors such as FeTe1−xSex will intrinsically trap non-Abelian Majorana quasiparticles, in the absence of any external magnetic field. Our theor...
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Open AccessCapturing ion trap** and detrap** dynamics in electrochromic thin films
Ion trap** has been found to be responsible for the performance degradation in electrochromic oxide thin films, and a detrap** procedure was proved to be effective to rejuvenate the degraded films. Despite...
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Open AccessControlled formation of three-dimensional cavities during lateral epitaxial growth
Epitaxial growth is a fundamental step required to create devices for the semiconductor industry, enabling different materials to be combined in layers with precise control of strain and defect structure. Patt...
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Open AccessDeciphering the contributing motifs of reconstructed cobalt (II) sulfides catalysts in Li-CO2 batteries
Develo** highly efficient catalysts is significant for Li-CO2 batteries. However, understanding the exact structure of catalysts during battery operation remains a challenge, which hampers knowledge-driven opti...
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Open AccessGlobal fungal-host interactome map** identifies host targets of candidalysin
Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we perfo...
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Open AccessPredictive potentials of glycosylation-related genes in glioma prognosis and their correlation with immune infiltration
Glycosylation is currently considered to be an important hallmark of cancer. However, the characterization of glycosylation-related gene sets has not been comprehensively analyzed in glioma, and the relationsh...
