Pulmonary Hypertension
Basic Science to Clinical Medicine
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Pulmonary hypertension and chronic kidney disease: prevalence, pathophysiology and outcomes
Pulmonary hypertension (PH) is common in patients with chronic kidney disease (CKD) or kidney failure, with an estimated prevalence of up to 78% in those referred for right-heart catheterization. PH is indepen...
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Open AccessSingle Cell Atlas: a single-cell multi-omics human cell encyclopedia
Single-cell sequencing datasets are key in biology and medicine for unraveling insights into heterogeneous cell populations with unprecedented resolution. Here, we construct a single-cell multi-omics map of hu...
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Open AccessAuthor Correction: Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
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Open AccessAssociation Between Circulating CD4+ T Cell Methylation Signatures of Network-Oriented SOCS3 Gene and Hemodynamics in Patients Suffering Pulmonary Arterial Hypertension
Pathogenic DNA methylation changes may be involved in pulmonary arterial hypertension (PAH) onset and its progression, but there is no data on potential associations with patient-derived hemodynamic parameters...
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Open AccessAuthor Correction: Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
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The Right Ventricle: From Embryologic Development to RV Failure
The right ventricle (RV) and left ventricle (LV) have different developmental origins, which likely plays a role in their chamber-specific response to physiological and pathological stress. RV dysfunction is e...
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Chronic Thromboembolic Pulmonary Hypertension: the Bench
Chronic thromboembolic pulmonary hypertension (CTEPH) is an uncommon complication of acute pulmonary embolism (PE), in which the red, platelet-rich thrombus does not resolve but forms into an organized yellow,...
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Chronic Thromboembolic Pulmonary Hypertension: the Bedside
Chronic thromboembolic pulmonary hypertension (CTEPH), included in group 4 PH, is an uncommon complication of acute pulmonary embolism (PE), in which emboli in the pulmonary vasculature do not resolve but rath...
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Open AccessClinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside
Despite impressive efforts invested in epigenetic research in the last 50 years, clinical applications are still lacking. Only a few university hospital centers currently use epigenetic biomarkers at the bedsi...
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Open AccessIndividualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
Progress in precision medicine is limited by insufficient knowledge of transcriptomic or proteomic features in involved tissues that define pathobiological differences between patients. Here, myectomy tissue f...
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Open AccessA global network for network medicine
Network Medicine is now an established scientific discipline, having generated key insights on integrated mechanisms underlying complex human diseases. The next discovery phase will emphasize innovating analyt...
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Pulmonary Hypertension: Pathophysiology and Signaling Pathways
Pulmonary hypertension (PH) is characterized by pathological changes to cell signaling pathways within the alveolar-pulmonary arteriole–right ventricular axis that results in increases in pulmonary vascular re...
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Correction: Corrigendum: Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity
Nat. Med. 13, 189–197 (2007); published online 4 February 2007; corrected after print 4 September 2009 In the version of this article initially published, the number of one of the grants listed in the Acknowle...
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Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity
Hyperaldosteronism is associated with impaired vascular reactivity; however, the mechanisms by which aldosterone promotes endothelial dysfunction remain unknown. Glucose-6-phosphate dehydrogenase (G6PD) modula...
