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Article
Open AccessComplex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
GABAB receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show that sequence-related epitopes in APP, AJAP-1 a...
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Article
Native GABAB receptors are heteromultimers with a family of auxiliary subunits
A proteomics study of GABAB receptors, the receptors for γ-aminobutyric acid, the main inhibitory neurotransmitter in the brain, throws new light on the origin of their functional diversity. Rather than being het...
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Article
Presynaptic glycine receptors enhance transmitter release at a mammalian central synapse
Glycine and GABAA (γ-aminobutyric acid A) receptors are inhibitory neurotransmitter-gated Cl- channels localized in postsynaptic membranes. In some cases, GABAA receptors are also found presynaptically, but they ...