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  1. No Access

    Chapter

    Regulation of Neurotransmitter Release by K+ Channels

    K+ channels play potent roles in the process of neurotransmitter release by influencing the action potential waveform and modulating neuronal excitability and release probability. These diverse effects of K+ chan...

    Zhao-Wen Wang, Laurence O. Trussell… in Molecular Mechanisms of Neurotransmitter R… (2023)

  2. No Access

    Chapter

    Microcircuits of the Dorsal Cochlear Nucleus

    The dorsal cochlear nucleus (DCN) integrates excitatory input from auditory and nonauditory sources. Auditory signals are conveyed to the deep layer by the auditory nerve and by excitatory interneurons in the ...

    Laurence O. Trussell, Donata Oertel in The Mammalian Auditory Pathways (2018)

  3. No Access

    Article

    Regulation of interneuron excitability by gap junction coupling with principal cells

    Electrical coupling in the brain usually occurs between inhibitory neurons that are anatomically and functionally similar. Here the authors show that the excitability of inhibitory interneurons in the dorsal c...

    Pierre F Apostolides, Laurence O Trussell in Nature Neuroscience (2013)

  4. No Access

    Book

    Synaptic Mechanisms in the Auditory System

    Laurence O. Trussell, Arthur N. Popper… in Springer Handbook of Auditory Research (2012)

  5. No Access

    Chapter

    Sound and Synapse

    This volume is an expression of the ongoing application of the concepts and ­techniques of cellular neurophysiology and cell biology to understanding auditory function. Embedded in this application is a story ...

    Laurence O. Trussell in Synaptic Mechanisms in the Auditory System (2012)

  6. No Access

    Chapter

    Inhibitory Neurons in the Auditory Brainstem

    Most chapters in this volume address the function of the major excitatory synapses in the lower auditory pathways, with respect to coincidence detection, the ion channels that determine neuronal firing, and th...

    Laurence O. Trussell in Synaptic Mechanisms in the Auditory System (2012)

  7. No Access

    Article

    Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport

    The authors report that rat brain glutamatergic synaptic vesicles express monovalent cation/H+ exchangers that convert the Δψ of the proton electrochemical gradient into Δψ. They find that this K+/H+ exchange sti...

    Germaine Y Goh, Hai Huang, Julie Ullman, Lars Borre, Thomas S Hnasko… in Nature Neuroscience (2011)

  8. No Access

    Article

    KCNQ5 channels control resting properties and release probability of a synapse

    Huang and Trussell show that resting potential of the calyx of Held synapse is controlled by KCNQ5 potassium channels. Unlike most KCNQ channels, which activate only on depolarization, these presynaptic channe...

    Hai Huang, Laurence O Trussell in Nature Neuroscience (2011)

  9. No Access

    Article

    Slow glycinergic transmission mediated by transmitter pooling

    Fast-acting neurotransmitters are usually cleared quickly from synaptic regions, making the time course of synaptic responses independent of active sites. The authors describe an exception to this rule at glyc...

    Veeramuthu Balakrishnan, Sidney P Kuo, Patrick D Roberts… in Nature Neuroscience (2009)

  10. No Access

    Chapter

    The Role of Potassium Channels in the Regulation of Neurotransmitter Release

    Neurotransmitter release is critically dependent on the duration of the presynaptic action potential. A variety of K+ channels play key roles in determining spike width. Moreover, K+ channels control how readily ...

    Laurence O. Trussell… in Molecular Mechanisms of Neurotransmitter Release (2008)

  11. No Access

    Article

    Cell-specific, spike timing–dependent plasticities in the dorsal cochlear nucleus

    In the dorsal cochlear nucleus, long-term synaptic plasticity can be induced at the parallel fiber inputs that synapse onto both fusiform principal neurons and cartwheel feedforward inhibitory interneurons. He...

    Thanos Tzounopoulos, Yuil Kim, Donata Oertel, Laurence O Trussell in Nature Neuroscience (2004)

  12. No Access

    Article

    Transmission at the hair cell synapse

    In cochlear hair cells, each transmitter release site communicates information about sound frequency and intensity. Now the first direct electrophysiological recordings from the structures postsynaptic to thes...

    Laurence O. Trussell in Nature Neuroscience (2002)

  13. No Access

    Chapter

    Cellular Mechanisms for Information Coding in Auditory Brainstem Nuclei

    The brainstem auditory nuclei carry out a wide variety of transformations of the signals carried by the auditory nerve. Although basic frequency and intensity information is first encoded in the cochlea, brain...

    Laurence O. Trussell in Integrative Functions in the Mammalian Auditory Pathway (2002)

  14. No Access

    Article

    Presynaptic glycine receptors enhance transmitter release at a mammalian central synapse

    Glycine and GABAA (γ-aminobutyric acid A) receptors are inhibitory neurotransmitter-gated Cl- channels localized in postsynaptic membranes. In some cases, GABAA receptors are also found presynaptically, but they ...

    Rostislav Turecek, Laurence O. Trussell in Nature (2001)

  15. No Access

    Chapter

    Cytoplasmic Modulation of Transmitter Gated K Channels in Cultured Mammalian Central Neurons

    Recent years have seen considerable progress in our understanding of slow inhibitory synaptic processes in the mammalian brain. In many studies a surprisingly similar mechanism of inhibition has emerged, thoug...

    Jerrel L. Yakel, Laurence O. Trussell… in Calcium and Ion Channel Modulation (1988)