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Article
Open AccessReduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice
The schizophrenia-associated gene, BRD1, encodes an epigenetic regulator in which chromatin interactome is enriched with genes implicated in mental health. Alterations in histone modifications and epigenetic regu...
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Article
An integrative systems genetic analysis of mammalian lipid metabolism
Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and progression of hepatosteatosis and metabolic syndrome. These conditions are highly prevalent in developed societies and curre...
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Article
Open AccessExperimental validation of methods for differential gene expression analysis and sample pooling in RNA-seq
Massively parallel cDNA sequencing (RNA-seq) experiments are gradually superseding microarrays in quantitative gene expression profiling. However, many biologists are uncertain about the choice of differential...
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Article
Open AccessIntegrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis
Allergic rhinitis is a common disease whose genetic basis is incompletely explained. We report an integrated genomic analysis of allergic rhinitis.
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Chapter and Conference Paper
Online Social Networks Flu Trend Tracker: A Novel Sensory Approach to Predict Flu Trends
Seasonal influenza epidemics cause several million cases of illnesses cases and about 250,000 to 500,000 deaths worldwide each year. Other pandemics like the 1918 “Spanish Flu” may change into devastating even...
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Article
Open AccessGenetic adaptation of the antibacterial human innate immunity network
Pathogens have represented an important selective force during the adaptation of modern human populations to changing social and other environmental conditions. The evolution of the immune system has therefore...
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Article
Open AccessQuantifying differential gene connectivity between disease states for objective identification of disease-relevant genes
Network modeling of whole transcriptome expression data enables characterization of complex epistatic (gene-gene) interactions that underlie cellular functions. Though numerous methods have been proposed and s...
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Article
Open AccessComprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes
Prior studies suggest a role for a variant (rs5743836) in the promoter of toll-like receptor 9 (TLR9) in asthma and other inflammatory diseases. We performed detailed genetic association studies of the functio...
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Article
Open AccessAsthma-susceptibility variants identified using probands in case-control and family-based analyses
Asthma is a chronic respiratory disease whose genetic basis has been explored for over two decades, most recently via genome-wide association studies. We sought to find asthma-susceptibility variants by using ...
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Chapter
Automated, High-throughput Surveillance Systems for Public Health
Modern public health is a relatively recent innovation, a mid-nineteenth century response to explosive epidemics of infectious diseases, including plague, influenza, and cholera, that periodically ravaged huma...
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Article
Open AccessPlatform dependence of inference on gene-wise and gene-set involvement in human lung development
With the recent development of microarray technologies, the comparability of gene expression data obtained from different platforms poses an important problem. We evaluated two widely used platforms, Affymetri...
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Article
Identification of 54 large deletions/duplications in TSC1 and TSC2 using MLPA, and genotype-phenotype correlations
Tuberous sclerosis (TSC) is an autosomal dominant disorder caused by mutations in either of two genes, TSC1 and TSC2. Point mutations and small indels account for most TSC1 and TSC2 mutations. We examined 261 TSC...
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Article
Open AccessDistributed data processing for public health surveillance
Many systems for routine public health surveillance rely on centralized collection of potentially identifiable, individual, identifiable personal health information (PHI) records. Although individual, identifi...
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Article
Open AccessExtracting principal diagnosis, co-morbidity and smoking status for asthma research: evaluation of a natural language processing system
The text descriptions in electronic medical records are a rich source of information. We have developed a Health Information Text Extraction (HITEx) tool and used it to extract key findings for a research stud...
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Article
Open AccessComparison of linkage and association strategies for quantitative traits using the COGA dataset
Genome scans using dense single-nucleotide polymorphism (SNP) data have recently become a reality. It is thought that the increase in information content for linkage analysis as a result of the denser scans wi...
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Article
Open AccessGenomic screening in family-based association testing
Due to the recent gains in the availability of single-nucleotide polymorphism data, genome-wide association testing has become feasible. It is hoped that this additional data may confirm the presence of diseas...
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Article
Open AccessPolymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in t...
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Article
Open AccessUsing automated medical records for rapid identification of illness syndromes (syndromic surveillance): the example of lower respiratory infection
Gaps in disease surveillance capacity, particularly for emerging infections and bioterrorist attack, highlight a need for efficient, real time identification of diseases.
