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within Rosemary J. Cater Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. No Access

    Article

    Structural and molecular basis of choline uptake into the brain by FLVCR2

    Choline is an essential nutrient that the human body needs in vast quantities for cell membrane synthesis, epigenetic modification and neurotransmission. The brain has a particularly high demand for choline, b...

    Rosemary J. Cater, Dibyanti Mukherjee, Eva Gil-Iturbe, Satchal K. Erramilli… in Nature (2024)

  2. Article

    Open Access

    Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A

    Major Facilitator Superfamily Domain containing 2 A (MFSD2A) is a transporter that is highly enriched at the blood-brain and blood-retinal barriers, where it mediates Na+-dependent uptake of ω−3 fatty acids in th...

    Shana Bergman, Rosemary J. Cater, Ambrose Plante, Filippo Mancia… in Nature Communications (2023)

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  3. No Access

    Article

    Structural basis of omega-3 fatty acid transport across the blood–brain barrier

    Docosahexaenoic acid is an omega-3 fatty acid that is essential for neurological development and function, and it is supplied to the brain and eyes predominantly from dietary sources1–6. This nutrient is transpor...

    Rosemary J. Cater, Geok Lin Chua, Satchal K. Erramilli, James E. Keener… in Nature (2021)

  4. No Access

    Article

    Glutamate transporters have a chloride channel with two hydrophobic gates

    Glutamate is the most abundant excitatory neurotransmitter in the central nervous system, and its precise control is vital to maintain normal brain function and to prevent excitotoxicity1. The removal of extracel...

    Ichia Chen, Shashank Pant, Qianyi Wu, Rosemary J. Cater, Meghna Sobti… in Nature (2021)