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Open AccessEpiDiP/NanoDiP: a versatile unsupervised machine learning edge computing platform for epigenomic tumour diagnostics
DNA methylation analysis based on supervised machine learning algorithms with static reference data, allowing diagnostic tumour ty** with unprecedented precision, has quickly become a new standard of care. W...
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Open AccessHost fecal DNA specific methylation signatures mark gut dysbiosis and inflammation in children affected by autism spectrum disorder
The gut-brain axis involves several bidirectional pathway communications including microbiome, bacterial metabolites, neurotransmitters as well as immune system and is perturbed both in brain and in gastrointe...
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Article
Open AccessTargeted inhibition of the methyltransferase SETD8 synergizes with the Wee1 inhibitor adavosertib in restraining glioblastoma growth
Despite intense research efforts, glioblastoma remains an incurable brain tumor with a dismal median survival time of 15 months. Thus, identifying new therapeutic targets is an urgent need. Here, we show that ...
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Open AccessDNA methylation-based classification of sinonasal tumors
The diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum of various differential diagnoses as well as poorly defined, disputed entities such as sinonasal undifferentiated carcinomas (SN...
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Article
Workflow in the multidisciplinary management of glioma patients in everyday practice: how we do it
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Open AccessEpigenetic remodelling of Fxyd1 promoters in develo** heart and brain tissues
FXYD1 is a key protein controlling ion channel transport. FXYD1 exerts its function by regulating Na+/K+-ATPase activity, mainly in brain and cardiac tissues. Alterations of the expression level of the FXYD1 prot...
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Open AccessN6-isopentenyladenosine induces cell death through necroptosis in human glioblastoma cells
Targeting necroptosis is considered a promising therapeutic strategy in cancer, including Glioblastoma Multiforme (GBM), one of the most lethal brain tumors. Necroptosis is a mechanism of programmed cell death...
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Open AccessDNA methylation impact on Fabry disease
Fabry disease (FD) is a rare X-linked disease caused by mutations in GLA gene with consequent lysosomal accumulation of globotriaosylceramide (Gb3). Women with FD often show highly heterogeneous symptoms that ...
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Open AccessCell cycle checkpoint in cancer: a therapeutically targetable double-edged sword
Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation. These insults elicit activation of ce...
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Erratum: Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit
Nature Communications 3: Article number: 894 (2012); Published: 12 June 2012; Updated: 15 January 2013. In Fig. 1 of this Article, the molecular weight markers are labelled incorrectly and 3F-Fcp1 is mistakenl...
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Open AccessFcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit
Correct execution of mitosis in eukaryotes relies on timely activation and inactivation of cyclin B-dependent kinase 1 (cdk1), the M-phase-promoting factor (MPF). Once activated, MPF is sustained until mitotic...
