9 Result(s)
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Article
Open AccessSingle cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis
Multiple myeloma is a plasma cell malignancy almost always preceded by precursor conditions, but low tumor burden of these early stages has hindered the study of their molecular programs through bulk sequencin...
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Article
Open AccessGenetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes
Smoldering multiple myeloma (SMM) is a precursor condition of multiple myeloma (MM) with significant heterogeneity in disease progression. Existing clinical models of progression risk do not fully capture this...
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Article
Single-cell profiling of tumour evolution in multiple myeloma — opportunities for precision medicine
Multiple myeloma (MM) is a haematological malignancy of plasma cells characterized by substantial intraclonal genetic heterogeneity. Although therapeutic advances made in the past few years have led to improve...
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Article
Inflammatory stromal cells in the myeloma microenvironment
Single-cell RNA sequencing identifies an inflammatory subpopulation of mesenchymal stromal cells in patients with multiple myeloma.
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Article
Single-cell RNA sequencing: one step closer to the clinic
Single-cell RNA-sequencing can help in the prediction of drug resistance in patients with multiple myeloma.
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Article
Open AccessClonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant
Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somat...
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Article
Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma
Precursor states of multiple myeloma (MM) and its native tumor microenvironment need in-depth molecular characterization to better stratify and treat patients at risk. Using single-cell RNA sequencing of bone ...
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Article
Acute lymphoblastic leukemia as a clonally unrelated second primary malignancy after multiple myeloma
Multiple myeloma (MM) patients have an 11-fold increased risk of develo** myeloid neoplasms compared to the general population; however, acute lymphoblastic leukemia (ALL) is rarely observed. Given that both...
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Primary hyperparathyroidism and the road to surgery: appraisal of the proceedings of the four international workshops (1990, 2002, 2008, 2014) on primary hyperparathyroidism
Although surgery is unambiguously recommended for symptomatic primary hyperparathyroidism (PHPT) patients, management options for asymptomatic patients have varied between surgery, medications and follow-up. T...
