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Article
Open AccessMicrofluidic cell sorting by stiffness to examine heterogenic responses of cancer cells to chemotherapy
Cancers consist of a heterogeneous populations of cells that may respond differently to treatment through drug-resistant sub-populations. The scarcity of these resistant sub-populations makes it challenging to...
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Article
Open AccessTargeted in vivo delivery of EGFR siRNA inhibits ovarian cancer growth and enhances drug sensitivity
A functionalized nanohydrogel siRNA delivery system and a mouse model of serous ovarian cancer were used to test predictions from previous cell line studies that knockdown of EGFR (epidermal growth factor rece...
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Article
Open AccessHuman papillomavirus infection and p16 expression in the immunocompetent patients with extragenital/extraungual Bowen’s disease
The role of human papillomaviruses (HPV) in the development of squamous cell carcinoma (SCC) has been established for anogenital lesions but still remains controversial for carcinomas in other sites. The aim o...
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Article
Open AccessSnail-induced epithelial-to-mesenchymal transition of MCF-7 breast cancer cells: systems analysis of molecular changes and their effect on radiation and drug sensitivity
Epithelial-to-mesenchymal transition (EMT) has been associated with the acquisition of metastatic potential and the resistance of cancer cells to therapeutic treatments. MCF-7 breast cancer cells engineered to co...
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Article
Open AccessHighly-accurate metabolomic detection of early-stage ovarian cancer
High performance mass spectrometry was employed to interrogate the serum metabolome of early-stage ovarian cancer (OC) patients and age-matched control women. The resulting spectral features were used to estab...
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Article
Open AccessIdentification of inhibitors of ovarian cancer stem-like cells by high-throughput screening
Ovarian cancer stem cells are characterized by self-renewal capacity, ability to differentiate into distinct lineages, as well as higher invasiveness and resistance to many anticancer agents. Since they may be...
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Article
Open AccessThe effects of MicroRNA transfections on global patterns of gene expression in ovarian cancer cells are functionally coordinated
MicroRNAs (miRNAs) are a class of small RNAs that have been linked to a number of diseases including cancer. The potential application of miRNAs in the diagnostics and therapeutics of ovarian and other cancers...
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Article
Open AccessIdentification of metabolites with anticancer properties by computational metabolomics
Certain endogenous metabolites can influence the rate of cancer cell growth. For example, diacylglycerol, ceramides and sphingosine, NAD+ and arginine exert this effect by acting as signaling molecules, while car...
