-
Article
The changing relationship between metropolitan area population growth and central city decline in the US manufacturing belt
This study examines population losses for 13 major central cities in the manufacturing belt of the USA over the period 1950 to 2020. The percentage change in the population of in a central city is related to p...
-
Article
Open AccessHigh throughput, label-free isolation of circulating tumor cell clusters in meshed microwells
Extremely rare circulating tumor cell (CTC) clusters are both increasingly appreciated as highly metastatic precursors and virtually unexplored. Technologies are primarily designed to detect single CTCs and of...
-
Article
Open AccessLeveraging TCGA gene expression data to build predictive models for cancer drug response
Machine learning has been utilized to predict cancer drug response from multi-omics data generated from sensitivities of cancer cell lines to different therapeutic compounds. Here, we build machine learning mo...
-
Article
Open AccessMachine learning predicts individual cancer patient responses to therapeutic drugs with high accuracy
Precision or personalized cancer medicine is a clinical approach that strives to customize therapies based upon the genomic profiles of individual patient tumors. Machine learning (ML) is a computational metho...
-
Article
Open AccessDe novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance
Gene-fusion or chimeric transcripts have been implicated in the onset and progression of a variety of cancers. Massively parallel RNA sequencing (RNA-Seq) of the cellular transcriptome is a promising approach ...
-
Article
Open AccessEvidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs
High-throughput technologies have identified significant changes in patterns of mRNA expression over cancer development but the functional significance of these changes often rests upon the assumption that obs...
-
Article
Open AccessTargeted in vivo delivery of EGFR siRNA inhibits ovarian cancer growth and enhances drug sensitivity
A functionalized nanohydrogel siRNA delivery system and a mouse model of serous ovarian cancer were used to test predictions from previous cell line studies that knockdown of EGFR (epidermal growth factor rece...
-
Article
Open AccessSnail-induced epithelial-to-mesenchymal transition of MCF-7 breast cancer cells: systems analysis of molecular changes and their effect on radiation and drug sensitivity
Epithelial-to-mesenchymal transition (EMT) has been associated with the acquisition of metastatic potential and the resistance of cancer cells to therapeutic treatments. MCF-7 breast cancer cells engineered to co...
-
Article
Open AccessHighly-accurate metabolomic detection of early-stage ovarian cancer
High performance mass spectrometry was employed to interrogate the serum metabolome of early-stage ovarian cancer (OC) patients and age-matched control women. The resulting spectral features were used to estab...
-
Article
Open AccessIntegrated sequence and expression analysis of ovarian cancer structural variants underscores the importance of gene fusion regulation
Genomic rearrangements or structural variants (SVs) are one of the most common classes of mutations in cancer.
-
Article
Open AccessDistinct metabolic responses of an ovarian cancer stem cell line
Cancer metabolism is emerging as an important focus area in cancer research. However, the in vitro cell culture conditions under which much cellular metabolism research is performed differ drastically from in viv...
-
Article
Open AccessTranscriptional override: a regulatory network model of indirect responses to modulations in microRNA expression
Documented changes in levels of microRNAs (miRNA) in a variety of diseases including cancer are leading to their development as early indicators of disease, and as a potential new class of therapeutic agents. ...
-
Article
Open AccessSequence variation among members of the miR-200 microRNA family is correlated with variation in the ability to induce hallmarks of mesenchymal-epithelial transition in ovarian cancer cells
Epithelial-Mesenchymal Transition (EMT) is a transient and reversible (Mesenchymal-Epithelial Transition or MET) process by which epithelial cells acquire mesenchymal cell characteristics including reduced int...
-
Article
Open AccessMolecular profiling supports the role of epithelial-to-mesenchymal transition (EMT) in ovarian cancer metastasis
While metastasis ranks among the most lethal of all cancer-associated processes, on the molecular level, it remains one of the least well understood. One model that has gained credibility in recent years is th...
-
Article
Monetary Policy and the Housing Bubble
The causes of the housing bubble are investigated using Granger causality analysis and VAR modeling methods. The study employs the S&P/Case-Shiller aggregate 10 city monthly housing price index, available in t...
-
Article
Open AccessThe serum vaspin levels are reduced in Japanese chronic hemodialysis patients
Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified in genetically obese rats that correlates with insulin resistance and obesity in humans. Recently, we found that ...
-
Article
Open AccessIdentification of inhibitors of ovarian cancer stem-like cells by high-throughput screening
Ovarian cancer stem cells are characterized by self-renewal capacity, ability to differentiate into distinct lineages, as well as higher invasiveness and resistance to many anticancer agents. Since they may be...
-
Article
Open AccessThe effects of MicroRNA transfections on global patterns of gene expression in ovarian cancer cells are functionally coordinated
MicroRNAs (miRNAs) are a class of small RNAs that have been linked to a number of diseases including cancer. The potential application of miRNAs in the diagnostics and therapeutics of ovarian and other cancers...
-
Article
Isolation and characterization of stem-like cells from a human ovarian cancer cell line
Increasing evidence supports the existence of a subpopulation of cancer cells capable of self-renewal and differentiation into diverse cell lineages. These cancer stem-like or cancer-initiating cells (CICs) al...
-
Article
Open AccessCharacterization and potential functional significance of human-chimpanzee large INDEL variation
Although humans and chimpanzees have accumulated significant differences in a number of phenotypic traits since diverging from a common ancestor about six million years ago, their genomes are more than 98.5% i...
