19 Result(s)

Article

Oxygenation thresholds for invasive ventilation in hypoxemic respiratory failure: a target trial emulation in two cohorts

The optimal thresholds for the initiation of invasive ventilation in patients with hypoxemic respiratory failure are unknown. Using the saturation-to-inspired oxygen ratio (SF), we compared lower versus higher...

Christopher J. Yarnell, Federico Angriman, Bruno L. Ferreyro, Kuan Liu… in Critical Care (2023)

Article

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (...

Luis Felipe Reyes, Srinivas Murthy, Esteban Garcia-Gallo, Laura Merson… in Critical Care (2022)

Article

Twenty articles that critical care clinicians should read about COVID-19

Jennifer L. Y. Tsang, Alexandra Binnie, Robert A. Fowler in Intensive Care Medicine (2021)

Article

Variability in intensive care unit admission among pregnant and postpartum women in Canada: a nationwide population-based observational study

Pregnancy-related critical illness results in approximately 300,000 deaths globally each year. The objective was to describe the variation in ICU admission and the contribution of patient- and hospital-based f...

Kazuyoshi Aoyama, Ruxandra Pinto, Joel G. Ray, Andrea D. Hill… in Critical Care (2019)

Article

Ebola virus disease and critical illness

As of 20 May 2016 there have been 28,646 cases and 11,323 deaths resulting from the West African Ebola virus disease (EVD) outbreak reported to the World Health Organization. There continue to be sporadic flar...

Aleksandra Leligdowicz, William A. Fischer II, Timothy M. Uyeki… in Critical Care (2016)

Article

The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness

Patients with 2009 pandemic influenza A(H1N1pdm09)-related critical illness were frequently treated with systemic corticosteroids. While observational studies have reported significant corticosteroid-associate...

Jesse W. Delaney, Ruxandra Pinto, Jennifer Long, François Lamontagne… in Critical Care (2016)

Article

Risk factors for and prediction of mortality in critically ill medical–surgical patients receiving heparin thromboprophylaxis

Previous studies have suggested that prediction models for mortality should be adjusted for additional risk factors beyond the Acute Physiology and Chronic Health Evaluation (APACHE) score. Our objective was ...

Guowei Li, Lehana Thabane, Deborah J. Cook, Renato D. Lopes… in Annals of Intensive Care (2016)

Article

Critical care capacity in Canada: results of a national cross-sectional study

Intensive Care Units (ICUs) provide life-supporting treatment; however, resources are limited, so demand may exceed supply in the event of pandemics, environmental disasters, or in the context of an aging popu...

Robert A Fowler, Philip Abdelmalik, Gordon Wood, Denise Foster… in Critical Care (2015)

Article

Economic analyses of venous thromboembolism prevention strategies in hospitalized patients: a systematic review

Despite evidence-based guidelines for venous thromboembolism prevention, substantial variability is found in practice. Many economic evaluations of new drugs for thromboembolism prevention do not occur prospec...

Subarna Thirugnanam, Ruxandra Pinto, Deborah J Cook, William H Geerts… in Critical Care (2012)

Article

Duration of antibiotic therapy for bacteremia: a systematic review and meta-analysis

The optimal duration of antibiotic therapy for bloodstream infections is unknown. Shorter durations of therapy have been demonstrated to be as effective as longer durations for many common infections; similar ...

Thomas C Havey, Robert A Fowler, Nick Daneman in Critical Care (2011)

Article

Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysis

Pleural effusions are frequently drained in mechanically ventilated patients but the benefits and risks of this procedure are not well established.

Ewan C Goligher, Jerome A Leis, Robert A Fowler, Ruxandra Pinto… in Critical Care (2011)

Article

Erratum to: A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care

Christopher J Longo, Daren K Heyland, Harold N Fisher, Robert A Fowler… in Critical Care (2008)

Article

Clinical review: Critical care in the global context – disparities in burden of illness, access, and economics

World health care expenditures exceed US $4 trillion. However, there is marked variation in global health care spending, from upwards of US $7,000 per capita in the US to under US $25 per capita in most of sub...

Robert A Fowler, Neill KJ Adhikari, Satish Bhagwanjee in Critical Care (2008)

Article

A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care

Recombinant human activated protein C (APC) therapy has been shown to reduce short-term mortality in patients with severe sepsis. However, survivors of sepsis may have long-term complications affecting health-...

Christopher J Longo, Daren K Heyland, Harold N Fisher, Robert A Fowler… in Critical Care (2007)