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Article

Cholesterol accumulation impairs HIF-1α-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway

Lipid accumulation in macrophages (Mφs) is a hallmark of atherosclerosis. Yet, how lipid loading modulates Mφ inflammatory responses remains unclear. We endeavored to gain mechanistic insights into how pre-loa...

Kenneth K. Y. Ting, Pei Yu, Riley Dow, Hisham Ibrahim, Saraf Karim… in Scientific Reports (2024)