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Article
Open AccessThe relationship between sleep disturbance and aggressive behaviour among community-dwelling schizophrenia patients: a moderated mesomeric effect model
Sleep disturbance is the most common concern of patients with schizophrenia and can lead to a poor prognosis, a low survival rate and aggressive behaviour, posing a significant threat to social security and st...
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Article
Machine learning prediction models for diabetic kidney disease: systematic review and meta-analysis
Machine learning is increasingly recognized as a viable approach for identifying risk factors associated with diabetic kidney disease (DKD). However, the current state of real-world research lacks a comprehens...
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Article
Open AccessCholesterol accumulation impairs HIF-1α-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway
Lipid accumulation in macrophages (Mφs) is a hallmark of atherosclerosis. Yet, how lipid loading modulates Mφ inflammatory responses remains unclear. We endeavored to gain mechanistic insights into how pre-loa...
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Article
Open AccessFloods and cause-specific mortality in the UK: a nested case-control study
Floods are the most frequent weather-related disaster, causing significant health impacts worldwide. Limited studies have examined the long-term consequences of flooding exposure.
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Article
Integrating Bulk RNA and Single-Cell Sequencing Data Unveils Efferocytosis Patterns and ceRNA Network in Ischemic Stroke
Excessive inflammatory response following ischemic stroke (IS) injury is a key factor affecting the functional recovery of patients. The efferocytic clearance of apoptotic cells within ischemic brain tissue is...
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Open AccessThe incorporation of acetylated LAP-TGF-β1 proteins into exosomes promotes TNBC cell dissemination in lung micro-metastasis
Triple-negative breast cancer (TNBC) stands as the breast cancer subtype with the highest recurrence and mortality rates, with the lungs being the common site of metastasis. The pulmonary microenvironment play...
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Article
Open AccessAssociation between circadian physical activity trajectories and incident type 2 diabetes in the UK Biobank
Physical activity (PA) is linked to a decreased risk of type 2 diabetes mellitus (T2DM). However, the influence of circadian PA trajectories remains uncertain. This study aims to explore the optimal circadian ...
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Article
Health Impacts of Wildfire Smoke on Children and Adolescents: A Systematic Review and Meta-analysis
Wildfire smoke is associated with human health, becoming an increasing public health concern. However, a comprehensive synthesis of the current evidence on the health impacts of ambient wildfire smoke on child...
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Article
Correlated sensing with a solid-state quantum multisensor system for atomic-scale structural analysis
Develo** superior quantum sensing strategies ranging from ultrahigh precision measurements to complex structural analyses is at the heart of quantum technologies. Although strategies to enhance the sensing p...
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Article
Open AccessAssociation between the trajectory of ideal cardiovascular health metrics and incident chronic kidney disease among 27,635 older adults in northern China–a prospective cohort study
There is a lack of relevant studies evaluating the long-term impact of cardiovascular health factor (CVH) metrics on chronic kidney disease (CKD).
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Article
Open AccessWide-field Fourier magnetic imaging with electron spins in diamond
Wide-field magnetic imaging based on nitrogen-vacancy (NV) centers in diamond has been shown the applicability in material and biological science. However, the spatial resolution is limited by the optical diff...
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Article
Single-Cell Sequencing Reveals the Expression of Immune-Related Genes in Macrophages of Diabetic Kidney Disease
Diabetic kidney disease (DKD) is characterized by macrophage infiltration, which requires further investigation. This study aims to identify immune-related genes (IRGs) in macrophage and explore their potentia...
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Open AccessSodium-dependent glucose transporter 2 inhibitor alleviates renal lipid deposition and improves renal oxygenation levels in newly diagnosed type 2 diabetes mellitus patients: a randomized controlled trial
Sodium-dependent glucose transporter 2 inhibitor (SGLT2i) has the advantages of effectively lowering blood glucose levels and improving renal outcomes in diabetic patients. This study evaluated the effect of c...
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Open AccessThermal-activated escape of the bistable magnetic states in 2D Fe3GeTe2 near the critical point
Great effort has been made recently to investigate the phase transitions in two-dimensional (2D) magnets while leaving subtle quantification unsolved. Here, we demonstrate the thermal-activated escape in 2D Fe3Ge...
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Article
Open AccessEfficacy of minimally invasive tubular approaches for management of the lumbar spinal synovial cysts: a meta-analysis
The treatment of lumbar spinal synovial cysts (LSCs) which are relatively rare but can cause neurogenic dysfunction and intractable pain has been a controversial topic for many years. Surgical excision of LSCs...
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A Complete Classification on the Center-Focus Problem of a Generalized Cubic Kukles System with a Nilpotent Singular Point
In this paper, we study the center-focus problem for a generalized cubic Kukles system with a nilpotent singular point, which consists of a cubic system with an extra 4th-order term. A complete classification ...
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Article
Open AccessGlobal population exposure to landscape fire air pollution from 2000 to 2019
Wildfires are thought to be increasing in severity and frequency as a result of climate change1–5. Air pollution from landscape fires can negatively affect human health4–6, but human exposure to landscape fire-so...
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Article
Sorafenib inhibits doxorubicin-induced PD-L1 upregulation to improve immunosuppressive microenvironment in Osteosarcoma
Although undergoing conventional chemotherapy significantly improves the prognosis of Osteosarcoma, chemoresistance and failure of therapy is still a significant challenge. Furthermore, conventional chemothera...
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Article
Laparoscopic pectopexy with native tissue repair for pelvic organ prolapse
The use of mesh for vaginal repair is currently problematic; consequently, there is increased interest in native tissue repair. Combining native tissue repair with sufficient mesh-applied apical repair might p...
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Article
Open AccessClinical characteristics and host immunity responses of SARS-CoV-2 Omicron variant BA.2 with deletion of ORF7a, ORF7b and ORF8
The pathogenicity and virulence of the Omicron strain have weakened significantly pathogenesis of Omicron variants. Accumulating data indicated accessory proteins play crucial roles in host immune evasion and ...
