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Open AccessCrym-positive striatal astrocytes gate perseverative behaviour
Astrocytes are heterogeneous glial cells of the central nervous system1–3. However, the physiological relevance of astrocyte diversity for neural circuits and behaviour remains unclear. Here we show that a specif...
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Article
Open AccessA transcriptomic taxonomy of mouse brain-wide spinal projecting neurons
The brain controls nearly all bodily functions via spinal projecting neurons (SPNs) that carry command signals from the brain to the spinal cord. However, a comprehensive molecular characterization of brain-wi...
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Article
Open AccessA toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences
Astrocytes, one of the most prevalent cell types in the central nervous system (CNS), are critically involved in neural function. Genetically manipulating astrocytes is an essential tool in understanding and a...
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Article
Open AccessErythropoietin re-wires cognition-associated transcriptional networks
Recombinant human erythropoietin (rhEPO) has potent procognitive effects, likely hematopoiesis-independent, but underlying mechanisms and physiological role of brain-expressed EPO remained obscure. Here, we pr...
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Article
Open AccessMyelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
The incidence of Alzheimer’s disease (AD), the leading cause of dementia, increases rapidly with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing affects oligodendrocy...
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Author Correction: Divergent transcriptional regulation of astrocyte reactivity across disorders
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Open AccessBroad transcriptomic dysregulation occurs across the cerebral cortex in ASD
Neuropsychiatric disorders classically lack defining brain pathologies, but recent work has demonstrated dysregulation at the molecular level, characterized by transcriptomic and epigenetic alterations1–3. In aut...
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Article
Open AccessP300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells
Glioma stem cells (GSC) exhibit plasticity in response to environmental and therapeutic stress leading to tumor recurrence, but the underlying mechanisms remain largely unknown. Here, we employ single-cell and...
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Open AccessElk-1 regulates retinal ganglion cell axon regeneration after injury
Adult central nervous system (CNS) axons fail to regenerate after injury, and master regulators of the regenerative program remain to be identified. We analyzed the transcriptomes of retinal ganglion cells (RG...
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Open AccessTranscriptomic architecture of nuclei in the marmoset CNS
To understand the cellular composition and region-specific specialization of white matter — a disease-relevant, glia-rich tissue highly expanded in primates relative to rodents — we profiled transcriptomes of ...
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Article
Open AccessTranscription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice
The inability of neurons to regenerate long axons within the CNS is a major impediment to improving outcome after spinal cord injury, stroke, and other CNS insults. Recent advances have uncovered an intrinsic ...
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Open AccessThe effect of Rbfox2 modulation on retinal transcriptome and visual function
Rbfox proteins regulate alternative splicing, mRNA stability and translation. These proteins are involved in neurogenesis and have been associated with various neurological conditions. Here, we analyzed Rbfox2...
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Article
Open AccessLongitudinal RNA-Seq analysis of acute and chronic neurogenic skeletal muscle atrophy
Skeletal muscle is a highly adaptable tissue capable of changes in size, contractility, and metabolism according to functional demands. Atrophy is a decline in mass and strength caused by pathologic loss of my...
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Open AccessActivity-Dependent Regulation of Alternative Cleavage and Polyadenylation During Hippocampal Long-Term Potentiation
Long-lasting forms of synaptic plasticity that underlie learning and memory require new transcription and translation for their persistence. The remarkable polarity and compartmentalization of neurons raises q...