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  1. Article

    Open Access

    Investigation of vertical and horizontal transmission of Spiroplasma in ticks under laboratory conditions

    Many arthropods harbour bacterial symbionts, which are maintained by vertical and/or horizontal transmission. Spiroplasma is one of the most well-known symbionts of ticks and other arthropods. It is still unclear...

    Shohei Ogata, Rika Umemiya-Shirafuji, Kodai Kusakisako in Scientific Reports (2023)

  2. Article

    Open Access

    RNA activation in ticks

    RNA activation (RNAa) is a burgeoning area of research in which double-stranded RNAs (dsRNAs) or small activating RNAs mediate the upregulation of specific genes by targeting the promoter sequence and/or AU-ri...

    Kofi Dadzie Kwofie, Emmanuel Pacia Hernandez, Anisuzzaman in Scientific Reports (2023)

  3. Article

    Open Access

    Localization of secreted ferritin (FER2) in the embryos of the tick Haemaphysalis longicornis

    Despite the absence of a blood meal, embryogenesis involves many processes that require nutrients and other essential elements, including iron. Due to the lack of an external source of these nutrients, these r...

    Emmanuel Pacia Hernandez, Kei Shimazaki, Hiroko Niihara in Parasites & Vectors (2023)

  4. No Access

    Article

    Effect of α-Tocopheryloxy Acetic Acid on the Infection of Mice with Plasmodium berghei ANKA In Vivo and Humans with P. falciparum In Vitro

    Malarial parasites are susceptible to oxidative stress. The effects of α-tocopheryloxy acetic acid (α-TEA), a vitamin E analog, on infection by Plasmodium berghei ANKA and P. falciparum in mice and human red bloo...

    Nanang R. Ariefta, Aiko Kume, Yoshifumi Nishikawa, Tomoyo Taniguchi in Acta Parasitologica (2022)

  5. Article

    Open Access

    Data from expressed sequence tags from the organs and embryos of parthenogenetic Haemaphysalis longicornis

    Haemaphysalis longicornis is the most important tick species in Japan and has a wide range of vector capacity. Due to its veterinary and medical importance, this tick species has been used as a model for tick/vec...

    Rika Umemiya-Shirafuji, **lin Zhou, Min Liao, Badgar Battsetseg in BMC Research Notes (2021)

  6. Article

    Open Access

    Effect of α-tocopheryloxy acetic acid, a vitamin E derivative mitocan, on the experimental infection of mice with Plasmodium yoelii

    Malaria parasites are known to be vulnerable to oxidative stress. In this study, the effects of the administration of α-tocopheryloxy acetic acid (α-TEA), which is a vitamin E analogue mitocan, on Plasmodium yoel...

    Kasumi Kawamura, Aiko Kume, Rika Umemiya-Shirafuji, Shunji Kasai in Malaria Journal (2021)

  7. Article

    Open Access

    Subolesin vaccination inhibits blood feeding and reproduction of Haemaphysalis longicornis in rabbits

    Ticks can transmit numerous tick-borne pathogens and cause a huge economic loss to the livestock industry. Tick vaccines can contribute to the prevention of tick-borne diseases by inhibiting tick infestation o...

    Seung-Hun Lee, Jixu Li, Paul Franck Adjou Moumouni, Kiyoshi Okado in Parasites & Vectors (2020)

  8. Article

    Open Access

    Intracellular localization of vitellogenin receptor mRNA and protein during oogenesis of a parthenogenetic tick, Haemaphysalis longicornis

    Vitellogenin (Vg), a key molecule for oocyte development synthesized in the fat body during blood-feeding, is released into the hemolymph and then taken into the oocytes via Vg receptor (VgR) in ticks. Previously...

    Rika Umemiya-Shirafuji, Ryo Mihara, Kozo Fujisaki, Hiroshi Suzuki in Parasites & Vectors (2019)

  9. Article

    Erratum to: Transovarial persistence of Babesia ovata DNA in a hard tick, Haemaphysalis longicornis, in a semi-artificial mouse skin membrane feeding system

    The original version of the article unfortunately contained a mistake.

    Rika Umemiya-Shirafuji, Takeshi Hatta, Kazuhiro Okubo, Moeko Sato in Acta Parasitologica (2018)

  10. No Access

    Article

    Transovarial persistence of Babesia ovata DNA in a hard tick, Haemaphysalis longicornis, in a semi-artificial mouse skin membrane feeding system

    Bovine piroplasmosis, a tick-borne protozoan disease, is a major concern for the cattle industry worldwide due to its negative effects on livestock productivity. Toward the development of novel therapeutic and...

    Rika Umemiya-Shirafuji, Takeshi Hatta, Kazuhiro Okubo, Moeko Sato in Acta Parasitologica (2017)

  11. Article

    Open Access

    Establishment of a novel tick-Babesia experimental infection model

    Ticks are potent vectors of many deadly human and animal pathogens. Tick-borne babesiosis is a well-recognized malaria-like disease that occurs worldwide and recently has attracted increased attention as an em...

    Hiroki Maeda, Takeshi Hatta, M Abdul Alim, Daigo Tsubokawa in Scientific Reports (2016)

  12. Article

    Open Access

    2-Cys peroxiredoxin is required in successful blood-feeding, reproduction, and antioxidant response in the hard tick Haemaphysalis longicornis

    Ticks are obligate hematophagous arthropods that feed on vertebrate blood that contains iron. Ticks also concentrate host blood with iron; this concentration of the blood leads to high levels of iron in ticks....

    Kodai Kusakisako, Remil Linggatong Galay, Rika Umemiya-Shirafuji in Parasites & Vectors (2016)

  13. Article

    Open Access

    Emergence of multi-acaricide resistant Rhipicephalus ticks and its implication on chemical tick control in Uganda

    Acaricide failure has been on the rise in the western and central cattle corridor of Uganda. In this study, we identified the tick species associated with acaricide failure and determined their susceptibility ...

    Patrick Vudriko, James Okwee-Acai, Dickson Stuart Tayebwa in Parasites & Vectors (2016)

  14. No Access

    Protocol

    Host Immunization with Recombinant Proteins to Screen Antigens for Tick Control

    Ticks (Parasitiformes: Ixodida) are known for their obligate blood feeding habit and their role in transmitting pathogens to various vertebrate hosts. Tick control using chemical acaricides is extensively used...

    Remil Linggatong Galay, Takeshi Miyata, Rika Umemiya-Shirafuji in Vaccine Design (2016)

  15. No Access

    Article

    Evaluation of Eimeria krijgsmanni as a murine model for testing the efficacy of anti-parasitic agents

    Murine Eimeria spp. have been used as effective models of disease instead of large mammalian hosts such as cattle. We attempted to establish in vivo and in vitro assays using a murine intestinal protozoan, Eimeri...

    Toshinori Takeo, Tetsuya Tanaka, Makoto Matsubayashi, Masashi Tsujio in Acta Parasitologica (2015)

  16. Article

    Open Access

    Evaluation and comparison of the potential of two ferritins as anti-tick vaccines against Haemaphysalis longicornis

    Tick control is an essential aspect of controlling the spread of tick-borne diseases affecting humans and animals, but it presently faces several challenges. Development of an anti-tick vaccine is aimed at des...

    Remil Linggatong Galay, Takeshi Miyata, Rika Umemiya-Shirafuji in Parasites & Vectors (2014)

  17. No Access

    Article

    Host specificity and in vivo infectivities of the mouse coccidian parasites Eimeria krijgsmanni

    In the present study, infection experiments of E. krijgsmanni using various hosts were conducted to elucidate the host specificity among some animals and the infectivity to mouse strains. According to the results...

    Kazuki Hashimoto, Tetsuya Tanaka, Makoto Matsubayashi, Kyoko Endo in Acta Parasitologica (2014)

  18. No Access

    Article

    Adaptation and immunogenicity of Cryptosporidium parvum to immunocompetent mice

    The adaptation and immunogenisity of Cryptosporidium parvum isolated from Siberian chipmunks (SC1 strain) in immunocompetent (ICR) mice were examined. The oocysts were received to the severe combined immunodefici...

    Tomohide Matsuo, Yasuko Tsuge, Rika Umemiya-Shirafuji in Acta Parasitologica (2014)

  19. No Access

    Article

    Inhibitory effect of cyclophilin A from the hard tick Haemaphysalis longicornis on the growth of Babesia bovis and Babesia bigemina

    Haemaphysalis longicornis is known as one of the most important ticks transmitting Babesia parasites in East Asian countries, including Babesia ovata and Babesia gibsoni, as well as Theileria par...

    Hiroki Maeda, Damdinsuren Boldbaatar, Kodai Kusakisako in Parasitology Research (2013)

  20. No Access

    Article

    RNAi of the translation inhibition gene 4E-BP identified from the hard tick, Haemaphysalis longicornis, affects lipid storage during the off-host starvation period of ticks

    4E-BP, an eIF4E-binding protein, is well known as a cap-dependent translation inhibitor. Here, the 4E-BP homolog, Hl4E-BP, was isolated and identified from the hard tick Haemaphysalis longicornis. Hl4E-BP transcr...

    Aiko Kume, Damdinsuren Boldbaatar, Yuko Takazawa in Parasitology Research (2012)

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