-
Article
Open AccessStress–strain curve and elastic behavior of the fibrotic lung with usual interstitial pneumonia pattern during protective mechanical ventilation
Patients with acute exacerbation of lung fibrosis with usual interstitial pneumonia (EUIP) pattern are at increased risk for ventilator-induced lung injury (VILI) and mortality when exposed to mechanical venti...
-
Article
Effect of high flow nasal oxygen on inspiratory effort of patients with acute hypoxic respiratory failure and do not intubate orders
High flow nasal oxygen (HFNO) is recommended as a first-line respiratory support during acute hypoxic respiratory failure (AHRF) and represents a proportionate treatment option for patients with do not intubat...
-
Article
Open AccessPhysiological effects of lung-protective ventilation in patients with lung fibrosis and usual interstitial pneumonia pattern versus primary ARDS: a matched-control study
Although patients with interstitial pneumonia pattern (ILD-UIP) and acute exacerbation (AE) leading to severe acute respiratory failure may require invasive mechanical ventilation (MV), physiological data on l...
-
Article
Open AccessNasal pressure swings as the measure of inspiratory effort in spontaneously breathing patients with de novo acute respiratory failure
Excessive inspiratory effort could translate into self-inflicted lung injury, thus worsening clinical outcomes of spontaneously breathing patients with acute respiratory failure (ARF). Although esophageal mano...
-
Article
Predictors of respiratory decline in myotonic dystrophy type 1 (DM1): a longitudinal cohort study
We studied 33 patients affected by juvenile and adult myotonic dystrophy type 1 (DM1). The aim of the study was to assess clinical and laboratory parameters that could predict the requirement of noninvasive ve...
-
Article
Open AccessMarked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia are urgently required. Here we sh...
-
Article
Open AccessVentilatory support and mechanical properties of the fibrotic lung acting as a “squishy ball”
Protective ventilation is the cornerstone of treatment of patients with the acute respiratory distress syndrome (ARDS); however, no studies have yet established the best ventilatory strategy to adopt when pati...
-
Article
Open AccessSerial ultrasound assessment of diaphragmatic function and clinical outcome in patients with amyotrophic lateral sclerosis
Diaphragmatic assessment by ultrasound (US) is a non-invasive and useful method in the clinical management of patients with Amyotrophic Lateral Sclerosis (ALS). The aim of our observational study was to evalua...
-
Article
Open AccessAn uncommon cause of hemoptysis: aortobronchial fistula
Hemoptysis is a frequent sign of respiratory and non-respiratory diseases. While in most cases the underlying cause is rapidly identified, sometimes the real etiology might be misdiagnosed with dramatic delay ...
-
Article
Open AccessUltrasound-assessed diaphragmatic impairment is a predictor of outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease undergoing noninvasive ventilation
Ultrasound (US) evaluation of diaphragmatic dysfunction (DD) has proved to be a reliable technique in critical care. In this single-center prospective study, we investigated the impact of US-assessed DD on non...
-
Article
Open AccessAcute exacerbation of idiopathic pulmonary fibrosis: lessons learned from acute respiratory distress syndrome?
Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease characterized by progressive loss of lung function and poor prognosis. The so-called acute exacerbation of IPF (AE-IPF) may lead to severe hypoxem...
-
Article
Open AccessEffectiveness of pulmonary rehabilitation in patients with interstitial lung disease of different etiology: a multicenter prospective study
Recent evidences show that Pulmonary Rehabilitation (PR) is effective in patients with Interstitial Lung Disease (ILD). It is still unclear whether disease severity and/or etiology might impact on the reported...
-
Article
When Acute Respiratory Distress Syndrome is not ARDS
-
Article
An uncommon cause of weaning failure from mechanical ventilation
