19 Result(s)

Article

Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma

Transfer RNA dynamics contribute to cancer development through regulation of codon-specific messenger RNA translation. Specific aminoacyl-tRNA synthetases can either promote or suppress tumourigenesis. Here we...

Najla El-Hachem, Marine Leclercq, Miguel Susaeta Ruiz… in Nature Cell Biology (2024)

Article

ABPEPserver: a web application for documentation and analysis of substitutants

Cancer immunotherapy is implemented by identifying antigens that are presented on the cell surface of cancer cells and illicit T-cell response (Schumacher and Schreiber, Science 348:69–74, 2015; Waldman et al....

Abhijeet Pataskar, Jasmine Montenegro Navarro, Reuven Agami in BMC Cancer (2023)

Article

Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers

Resistance to platinum-based chemotherapy represents a major clinical challenge for many tumors, including epithelial ovarian cancer. Patients often experience several response-relapse events, until tumors bec...

Tom Van Nyen, Mélanie Planque, Lilian van Wagensveld… in Nature Communications (2022)

Article

Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos… in Nature (2022)

Article

Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors

Accumulating evidence identifies non-genetic mechanisms substantially contributing to drug resistance in cancer patients. Preclinical and clinical data implicate the transcriptional co-activators YAP1 and its ...

Sebastian M. Dieter, Domenica Lovecchio, Abhijeet Pataskar, Martina K. Zowada… in Oncogene (2022)

Article

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme^1–4. Here we show that despite tryptophan depletion, in-fram...

Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos… in Nature (2022)

Article

A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis

Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiv...

Li Li, Alejandro P. Ugalde, Colinda L. G. J. Scheele, Sebastian M. Dieter… in Genome Biology (2021)

Article

Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells

Somatic ribosomal protein mutations have recently been described in cancer, yet their impact on cellular transcription and translation remains poorly understood. Here, we integrate mRNA sequencing, ribosome fo...

Kim R. Kampen, Laura Fancello, Tiziana Girardi, Gianmarco Rinaldi… in Nature Communications (2019)

Article

Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence

Functional characterization of non-coding elements in the human genome is a major genomic challenge and the maturation of genome-editing technologies is revolutionizing our ability to achieve this task. Oncoge...

Ruiqi Han, Li Li, Alejandro Piñeiro Ugalde, Arieh Tal, Zohar Manber… in Genome Biology (2018)

Article

FcαRI co-stimulation converts human intestinal CD103⁺ dendritic cells into pro-inflammatory cells through glycolytic reprogramming

CD103⁺ dendritic cells (DC) are crucial for regulation of intestinal tolerance in humans. However, upon infection of the lamina propria this tolerogenic response is converted to an inflammatory response. Here we ...

Ivo S. Hansen, Lisette Krabbendam, Jochem H. Bernink… in Nature Communications (2018)

Article

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

p53 binds enhancers to regulate key target genes. Here, we globally mapped p53-regulated enhancers by looking at enhancer RNA (eRNA) production. Intriguingly, while many p53-induced enhancers contained p53-bin...

Nicolas Léveillé, Carlos A. Melo, Koos Rooijers… in Nature Communications (2015)

Article

Ribosome profiling reveals features of normal and disease-associated mitochondrial translation

Mitochondria are essential cellular organelles for generation of energy and their dysfunction may cause diabetes, Parkinson’s disease and multi-systemic failure marked by failure to thrive, gastrointestinal pr...

Koos Rooijers, Fabricio Loayza-Puch, Leo G. Nijtmans, Reuven Agami in Nature Communications (2013)

Article

eRNAs reach the heart of transcription

Recently, various studies shed light on the functional significance of enhancer RNAs. Two recent studies published in Nature by Li et al. and Lam et al. highlight the importance of these newly characterized RNA m...

Carlos A Melo, Nicolas Léveillé, Reuven Agami in Cell Research (2013)

Article

p53 induces transcriptional and translational programs to suppress cell proliferation and growth

Cell growth and proliferation are tightly connected to ensure that appropriately sized daughter cells are generated following mitosis. Energy stress blocks cell growth and proliferation, a critical response fo...

Fabricio Loayza-Puch, Jarno Drost, Koos Rooijers, Rui Lopes, Ran Elkon… in Genome Biology (2013)

Article

E2F mediates enhanced alternative polyadenylation in proliferation

The majority of mammalian genes contain multiple poly(A) sites in their 3' UTRs. Alternative cleavage and polyadenylation are emerging as an important layer of gene regulation as they generate transcript isofo...

Ran Elkon, Jarno Drost, Gijs van Haaften, Mathias Jenal, Mariette Schrier… in Genome Biology (2012)

Article

Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity

MicroRNAs (miRNAs) interact with 3′-untranslated regions of messenger RNAs to restrict expression of most protein-coding genes during normal development and cancer. RNA-binding proteins (RBPs) can control the ...

Nicolas Léveillé, Ran Elkon, Veronica Davalos… in Nature Communications (2011)

Article

Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer

A substantial number of microRNAs (miRNAs) is subject to epigenetic silencing in cancer. Although epigenetic silencing of tumour suppressor genes is an important feature of cervical cancer, little is known abo...

Saskia M Wilting, Robert AA van Boerdonk, Florianne E Henken… in Molecular Cancer (2010)

Article

Major role for mRNA stability in sha** the kinetics of gene induction

mRNA levels in cells are determined by the relative rates of RNA production and degradation. Yet, to date, most analyses of gene expression profiles were focused on mechanisms which regulate transcription, whi...

Ran Elkon, Eitan Zlotorynski, Karen I Zeller, Reuven Agami in BMC Genomics (2010)

Article

Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake

Several lines of evidence strongly suggest that agouti-related peptide (AGRP) plays a key role in the regulation of metabolic function but ablation of the AGRP gene has no apparent effect on metabolic function...

Hideo Makimura, Tooru M Mizuno, Jason W Mastaitis, Reuven Agami… in BMC Neuroscience (2002)