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The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes

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  1. Article

    eRNAs reach the heart of transcription

    Recently, various studies shed light on the functional significance of enhancer RNAs. Two recent studies published in Nature by Li et al. and Lam et al. highlight the importance of these newly characterized RNA m...

    Carlos A Melo, Nicolas Léveillé, Reuven Agami in Cell Research (2013)

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  2. Article

    Open Access

    Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors

    Accumulating evidence identifies non-genetic mechanisms substantially contributing to drug resistance in cancer patients. Preclinical and clinical data implicate the transcriptional co-activators YAP1 and its ...

    Sebastian M. Dieter, Domenica Lovecchio, Abhijeet Pataskar, Martina K. Zowada… in Oncogene (2022)

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  3. Article

    Open Access

    Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma

    Transfer RNA dynamics contribute to cancer development through regulation of codon-specific messenger RNA translation. Specific aminoacyl-tRNA synthetases can either promote or suppress tumourigenesis. Here we...

    Najla El-Hachem, Marine Leclercq, Miguel Susaeta Ruiz… in Nature Cell Biology (2024)

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