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  1. No Access

    Article

    The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes

    c-Abl, the non-receptor tyrosine kinase is associated with EP, a DNA element found in promoters/enhancers of different viruses and cell-cycle regulated genes. EP-DNA binds RFXI, a member of a novel family of D...

    Reuven Agami, Yosef Shaul in Oncogene (1998)

  2. No Access

    Article

    HBV integrants of hepatocellular carcinoma cell lines contain an active enhancer

    Hepatitis B virus (HBV) infection is a major risk factor worldwide for the development of hepatocellular carcinoma (HCC). Integrated HBV DNA fragments, often highly rearranged, are frequently detected in HCC. ...

    Meir Shamay, Reuven Agami, Yosef Shaul in Oncogene (2001)

  3. Article

    Open Access

    Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors

    Accumulating evidence identifies non-genetic mechanisms substantially contributing to drug resistance in cancer patients. Preclinical and clinical data implicate the transcriptional co-activators YAP1 and its ...

    Sebastian M. Dieter, Domenica Lovecchio, Abhijeet Pataskar, Martina K. Zowada… in Oncogene (2022)

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  4. No Access

    Article

    Molecular mechanisms of non-genetic aberrant peptide production in cancer

    The cancer peptidome has long been known to be altered by genetic mutations. However, more recently, non-genetic polypeptide mutations have also been related to cancer cells. These non-genetic mutations occur ...

    Demi Wernaart, Amos Fumagalli, Reuven Agami in Oncogene (2024)