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Article
EGFL6 promotes bone metastasis of lung adenocarcinoma by increasing cancer cell malignancy and bone resorption
Lung adenocarcinoma is the most common and aggressive type of lung cancer with the highest incidence of bone metastasis. Epidermal growth factor-like domain multiple 6 (EGFL6) is an e...
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Chapter
Motor Proteins and Spermatogenesis
Unlike the intermediate filament- and septin-based cytoskeletons which are apolar structures, the microtubule (MT) and actin cytoskeletons are polarized structures in mammalian cells and tissues including the ...
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Article
Open AccessEndogenously produced LG3/4/5-peptide protects testes against toxicant-induced injury
Laminin-α2 chain is one of the major constituent proteins of the basement membrane in the mammalian testis. The laminin-type globular (LG) domains of LG3, 4 and 5 (LG3/4/5, an 80 kDa fragment) can be cleaved f...
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Article
Differentiation of human umbilical cord mesenchymal stem cells into Leydig-like cells with defined molecular compounds
95% of the body’s testosterone is produced by the Leydig Cells (LCs) in adult testis, and LC functional degradation can cause testosterone deficiency ultimately leading towards hypogonadism. The transplantatio...
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Article
Open AccessDifferentiation of human induced pluripotent stem cells into Leydig-like cells with molecular compounds
Leydig cells (LCs) play crucial roles in producing testosterone, which is critical in the regulation of male reproduction and development. Low levels of testosterone will lead to male hypogonadism. LC transpla...
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Article
Open AccessPlanar cell polarity protein Dishevelled 3 (Dvl3) regulates ectoplasmic specialization (ES) dynamics in the testis through changes in cytoskeletal organization
In the mammalian testes, such as in rats, the directional alignment of polarized elongating/elongated spermatids, in particular step 17–19 spermatids, across the plane of seminiferous epithelium resembles plan...
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Article
Enrichment of cancer stem cells by agarose multi-well dishes and 3D spheroid culture
As the theory of cancer stem cells (CSCs) is maturing, CSC-targeted therapy is emerging as an important therapeutic strategy and seeking the ideal method for rapid enrichment and purification of CSCs has becom...
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Chapter
Perfluorinated Compound Exposure and Health Effects in Humans
Perfluorinated compounds (PFCs) include a large group of anthropogenic fluorinated organic substances. This chapter reviews the current understanding of the sources and trends of human exposure to PFCs and evi...
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Article
Extraction and detection of bisphenol A in human serum and urine by aptamer-functionalized magnetic nanoparticles
A new type of magnetic nanoparticles (MNPs), as the absorbents of bisphenol A (BPA), was prepared by functionalization of Fe3O4@SiO2 with BPA-specific aptamer in this work. ssDNA aptamer was immobilized on the Fe
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Article
Open AccessActin nucleator Spire 1 is a regulator of ectoplasmic specialization in the testis
Germ cell differentiation during the epithelial cycle of spermatogenesis is accompanied by extensive remodeling at the Sertoli cell–cell and Sertoli cell–spermatid interface to accommodate the transport of pre...
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Protocol
Monitoring the Integrity of the Blood-Testis Barrier (BTB): An In Vivo Assay
The blood-testis barrier is a unique ultrastructure in the mammalian testis, located near the basement membrane of the seminiferous tubule that segregates the seminiferous epithelium into the basal and the adl...
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Article
Open AccessOverexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression
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Article
Open AccessKIAA1199 as a potential diagnostic biomarker of rheumatoid arthritis related to angiogenesis
Our previous proteomic study on fibroblast-like synoviocytes (FLSs) derived from the synovial tissues found that the expression of KIAA1199 was higher in rheumatoid arthritis (RA) patients than in healthy cont...
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Chapter
The Role of the Leydig Cell in Spermatogenic Function
Two anatomically distinct compartments, respectively, the interstitium where Leydig cells reside and the seminiferous tubules contribute the major functions of the testis, testosterone secretion and sperm prod...
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Article
Stress hormone and male reproductive function
The Leydig cell is the primary source of testosterone in males. Levels of testosterone in circulation are determined by the steroidogenic capacities of individual Leydig cells and the total numbers of Leydig c...
