59 Result(s)

Article

Preparing for future pandemics: frailty associates with mortality in hospitalised older people during the entire COVID-19 pandemic, a Dutch multicentre cohort study

We aim to investigate how associations of frailty with in-hospital mortality changed throughout the pandemic in older people hospitalised for COVID-19.

Bas F. M. van Raaij, Raymond Noordam, Rosalinde A. L. Smits… in European Geriatric Medicine (2024)

Article

Genome-wide characterization of circulating metabolic biomarkers

Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism^1–7. This detailed knowledge of the genetic determinants of systemic me...

Minna K. Karjalainen, Savita Karthikeyan, Clare Oliver-Williams, Eeva Sliz… in Nature (2024)

Article

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes^1,2 and molecular mechanisms that are often specific to cell type^3,4. Here, to characterize the genetic c...

Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J. Taylor… in Nature (2024)

Article

Per- and Polyfluoroalkyl Substances Concentrations are Associated with an Unfavorable Cardio-Metabolic Risk Profile: Findings from Two Population-Based Cohort Studies

Per- and polyfluoroalkyl substances (PFAS) are widely used and persistent chemicals, leading to ubiquitous exposure. Although high PFAS levels have been associated with an adverse cardiovascular risk profile, ...

Tariq O. Faquih, Elvire N. Landstra, Astrid van Hylckama Vlieg… in Exposure and Health (2024)

Article

Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European anc...

Rosalie B. T. M. Sterenborg, Inga Steinbrenner, Yong Li… in Nature Communications (2024)

Article

X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements

X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association met...

Markus Scholz, Katrin Horn, Janne Pott, Matthias Wuttke… in Nature Communications (2024)

Article

Exploring the possible causal effects of cardiac blood biomarkers in dementia and cognitive performance: a Mendelian randomization study

Prospective cohort studies have implied associations between blood levels of troponin T, troponin I, NT-proBNP, GDF15, dementia, and cognitive function, without providing evidence favoring possible causality. ...

Michelle H. Zonneveld, Stella Trompet, J. Wouter Jukema, Raymond Noordam in GeroScience (2023)

Article

Genetic insights into resting heart rate and its role in cardiovascular disease

Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associate...

Yordi J. van de Vegte, Ruben N. Ep**a, M. Yldau van der Ende… in Nature Communications (2023)

Article

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham, Shoa L. Clarke, Kuan-Han H. Wu, Stavroula Kanoni… in Nature (2023)

Article

Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Usin...

William J. Young, Jeffrey Haessler, Jan-Walter Benjamins… in Nature Communications (2023)

Article

The association of measures of body shape and adiposity with incidence of cardiometabolic disease from an ageing perspective

While obesity increases the risk of develo** cardiometabolic diseases (CMDs), these associations seem to attenuate with increasing age, albeit studied poorly. The present study aimed to investigate the assoc...

Fleur L. Meulmeester, Ko Willems van Dijk, Simon P. Mooijaart… in GeroScience (2023)

Article

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understandi...

Stavroula Kanoni, Sarah E. Graham, Yuxuan Wang, Ida Surakka… in Genome Biology (2022)

Article

A saturated map of common genetic variants associated with human height

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sa...

Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, Eric Bartell… in Nature (2022)

Article

Assessment of the bi-directional relationship between blood mitochondrial DNA copy number and type 2 diabetes mellitus: a multivariable-adjusted regression and Mendelian randomisation study

Mitochondrial dysfunction, which can be approximated by blood mitochondrial DNA copy number (mtDNA-CN), has been implicated in the pathogenesis of type 2 diabetes mellitus. Thus far, however, insights from pro...

Wenyi Wang, Jiao Luo, Ko Willems van Dijk, Sara Hägg, Felix Grassmann… in Diabetologia (2022)

Article

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are ...

William J. Young, Najim Lahrouchi, Aaron Isaacs, ThuyVy Duong… in Nature Communications (2022)

Article

Systemic inflammatory markers in relation to cognitive function and measures of brain atrophy: a Mendelian randomization study

Observational studies have implied associations between multiple cytokines and cognitive decline, anti-inflammatory drugs however did not yield any protective effects on cognitive decline. We aimed to assess t...

Jiao Luo, Saskia le Cessie, Gerard Jan Blauw, Claudio Franceschi… in GeroScience (2022)

Article

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide associat...

Thomas W. Winkler, Humaira Rasheed, Alexander Teumer… in Communications Biology (2022)