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Open AccessCirculating cell-free mitochondrial DNA levels and glucocorticoid sensitivity in a cohort of male veterans with and without combat-related PTSD
Circulating cell-free mitochondrial DNA (ccf-mtDNA) is a biomarker of cellular injury or cellular stress and is a potential novel biomarker of psychological stress and of various brain, somatic, and psychiatri...
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Article
Open AccessEarly to sustained impacts of lethal radiation on circulating miRNAs in a minipig model
Early diagnosis of lethal radiation is imperative since its intervention time windows are considerably short. Hence, ideal diagnostic candidates of radiation should be easily accessible, enable to inform about...
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Article
Open AccessMeeting report of the sixth annual tri-service microbiome consortium symposium
The Tri-Service Microbiome Consortium (TSMC) was founded to enhance collaboration, coordination, and communication of microbiome research among DoD organizations and to facilitate resource, material and inform...
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Article
Open AccessSevere, short-term sleep restriction reduces gut microbiota community richness but does not alter intestinal permeability in healthy young men
Sleep restriction alters gut microbiota composition and intestinal barrier function in rodents, but whether similar effects occur in humans is unclear. This study aimed to determine the effects of severe, shor...
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Article
Open AccessRare copy number variation in posttraumatic stress disorder
Posttraumatic stress disorder (PTSD) is a heritable (h2 = 24–71%) psychiatric illness. Copy number variation (CNV) is a form of rare genetic variation that has been implicated in the etiology of psychiatric disor...
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Article
Open AccessDimensions of childhood adversity differentially affect biological aging in major depression
Adverse childhood experiences have been consistently linked with physical and mental health disorders in adulthood that may be mediated, in part, via the effects of such exposures on biological aging. Using re...
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Correction: A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessPre-deployment risk factors for PTSD in active-duty personnel deployed to Afghanistan: a machine-learning approach for analyzing multivariate predictors
Active-duty Army personnel can be exposed to traumatic warzone events and are at increased risk for develo** post-traumatic stress disorder (PTSD) compared with the general population. PTSD is associated wit...
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A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD
DNA methylation patterns at specific cytosine-phosphate-guanine (CpG) sites predictably change with age and can be used to derive “epigenetic age”, an indicator of biological age, as opposed to merely chronolo...
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Article
Open AccessEpigenetic biotypes of post-traumatic stress disorder in war-zone exposed veteran and active duty males
Post-traumatic stress disorder (PTSD) is a heterogeneous condition evidenced by the absence of objective physiological measurements applicable to all who meet the criteria for the disorder as well as divergent...
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Article
Open AccessLongitudinal genome-wide methylation study of PTSD treatment using prolonged exposure and hydrocortisone
Epigenetic changes are currently invoked as explanations for both the chronicity and tenacity of post-traumatic stress disorder (PTSD), a heterogeneous condition showing varying, sometimes idiosyncratic respon...
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Article
Open AccessUtilization of machine learning for identifying symptom severity military-related PTSD subtypes and their biological correlates
We sought to find clinical subtypes of posttraumatic stress disorder (PTSD) in veterans 6–10 years post-trauma exposure based on current symptom assessments and to examine whether blood biomarkers could differ...
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Article
Open Access“GrimAge,” an epigenetic predictor of mortality, is accelerated in major depressive disorder
Major depressive disorder (MDD) is associated with premature mortality and is an independent risk factor for a broad range of diseases, especially those associated with aging, such as cardiovascular disease, d...
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Article
Open AccessAnalysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites
With increased human presence in space, bone loss and fractures will occur. Thrombopoietin (TPO) is a recently patented bone healing agent. Here, we investigated the systemic effects of TPO on mice subjected t...
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Open AccessMulti-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limi...
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Article
Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity
Post-traumatic stress disorder (PTSD) is a debilitating disorder that develops in some people following trauma exposure. Trauma and PTSD have been associated with accelerated cellular aging. This study evaluat...
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Article
Open AccessmicroRNA and Metabolite Signatures Linked to Early Consequences of Lethal Radiation
Lethal total body irradiation (TBI) triggers multifactorial health issues in a potentially short time frame. Hence, early signatures of TBI would be of great clinical value. Our study aimed to interrogate microRN...
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Article
Open AccessGenomic influences on self-reported childhood maltreatment
Childhood maltreatment is highly prevalent and serves as a risk factor for mental and physical disorders. Self-reported childhood maltreatment appears heritable, but the specific genetic influences on this phe...
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Article
Open AccessTemporal analysis of mRNA expression profiles in Orientia infected C3HeB/FeJ mouse
Scrub typhus causes up to 35% mortality if left untreated. One billion people living in the endemic regions are at risk. In spite of its heavy disease burden in some of the most populated areas in the world, t...
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Open AccessInternational meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 contr...
