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Article
Open AccessCGRP-targeted medication in chronic migraine - systematic review
Chronic migraine is a highly debilitating condition that is often difficult to manage, particularly in the presence of medication overuse headache. Drugs targeting the calcitonin gene-related peptide (CGRP), o...
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Article
Open AccessWorking memory during spontaneous migraine attacks: an fMRI study
To investigate the neural correlates of working memory during a spontaneous migraine attack compared to the interictal phase, using functional magnetic resonance imaging (fMRI).
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Article
Open AccessImpact of truncating diffusion MRI scans on diffusional kurtosis imaging
Diffusional kurtosis imaging (DKI) extends diffusion tensor imaging (DTI), characterizing non-Gaussian diffusion effects but requires longer acquisition times. To ensure the robustness of DKI parameters, data ...
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Article
Open AccessRethinking headache as a global public health case model for reaching the SDG 3 HEALTH by 2030
The 2030 Agenda for Sustainable Development sets out, through 17 Sustainable Development Goals (SDGs), a path for the prosperity of people and the planet. SDG 3 in particular aims to ensure healthy lives and p...
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Article
Open AccessEuropean Headache Federation (EHF) critical reappraisal and meta-analysis of oral drugs in migraine prevention – part 3: topiramate
Topiramate is a repurposed first-line treatment for migraine prophylaxis. The aim of this systematic review and meta-analysis is to critically re-appraise the existing evidence supporting the efficacy and tole...
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Article
Open AccessEuropean Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention—part 2: flunarizine
Novel disease-specific and mechanism-based treatments sharing good evidence of efficacy for migraine have been recently marketed. However, reimbursement by insurers depends on treatment failure with classic an...
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Article
Open AccessThe comparative effectiveness of migraine preventive drugs: a systematic review and network meta-analysis
While there are several trials that support the efficacy of various drugs for migraine prophylaxis against placebo, there is limited evidence addressing the comparative safety and efficacy of these drugs. We c...
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Article
Open AccessEuropean Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention—part 1: amitriptyline
The aim of this paper is to critically re-appraise the published trials assessing amitriptyline for migraine prophylaxis.
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Article
Open AccessEuropean Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failure
Triptans are migraine-specific acute treatments. A well-accepted definition of triptan failure is needed in clinical practice and for research. The primary aim of the present Consensus was to provide a definit...
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Article
Open AccessEuropean Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 update
A previous European Headache Federation (EHF) guideline addressed the use of monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway to prevent migraine. Since then, randomized contr...
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Article
Persistent monocular visual loss in migraine patients
The relationship between migraine and vision is complex. Besides migraine aura status and persistent visual aura without infarction, recognized by International Headaches Classification 3, cases of persistent ...
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Article
Open AccessTIME, to move forward? comment on “a universal outcome measure for headache treatments, care-delivery systems and economic analysis”
The paper from Steiner et al. suggests that an outcome measure expressed in time units may be an adequate method to assess the impact of headache disorders, regardless of diagnosis or health care setting, prov...
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Article
Headache Gauge: a real-life calendar-based tool for headache monitoring
This study aimed to validate a semi-quantitative composite score tool, “Headache Gauge” (HG), to monitor the treatment effect in primary headaches in everyday clinic practice, adjustable to any chosen timeframe.
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Article
Open AccessStructured headache services as the solution to the ill-health burden of headache: 1. Rationale and description
In countries where headache services exist at all, their focus is usually on specialist (tertiary) care. This is clinically and economically inappropriate: most headache disorders can effectively and more effi...
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Article
Open AccessCognitive aging in migraine sufferers is associated with more subjective complaints but similar age-related decline: a 5-year longitudinal study
The effect of headache on cognitive performance is controversial, due to conflicting results obtained from studies in clinical or population settings. We aimed to understand if migraine and other headaches mod...
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Article
Cognition and Cognitive Impairment in Migraine
Migraine is a complex neurological disorder that affects a significant percentage of the human species, from all geographic areas and cultures. Cognitive symptoms and dysfunctions are interim and disabling com...
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Evaluation: Quality in Headache Services
This chapter sets out a multidimensional definition of quality in the context of headache care, along with a related set of quality indicators currently undergoing evaluation. Both were developed for the purposes...
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Article
Open AccessHeadache service quality: evaluation of quality indicators in 14 specialist-care centres
The study was a collaboration between Lifting The Burden (LTB) and the European Headache Federation (EHF). Its aim was to evaluate the implementation of quality indicators for headache care Europe-wide in special...
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Article
Open AccessEvaluation of headache service quality indicators: pilot implementation in two specialist-care centres
Evaluating quality of health care is increasingly recognized as an important contributor to the advancement of health-care delivery. We recently developed a set of quality indicators for headache care, intende...
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Article
Assessment of cognitive dysfunction during migraine attacks: a systematic review
Patients consistently report cognitive impairment during migraine attacks, yet the documentation of such dysfunction by neuropsychological evaluation has lacked similar consistency. This incongruence may be du...
