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Article
Open AccessTransient Triplet Differential (TTD) Method for Background Free Photoacoustic Imaging
With the capability of presenting endogenous tissue contrast or exogenous contrast agents in deep biological samples at high spatial resolution, photoacoustic (PA) imaging has shown significant potential for m...
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Article
Open AccessIn vivo quantitative imaging of tumor pH by nanosonophore assisted multispectral photoacoustic imaging
Changes of physiological pH are correlated with several pathologies, therefore the development of more effective medical pH imaging methods is of paramount importance. Here, we report on an in vivo pH map** ...
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Article
Nature of segregation of reactants in diffusion controlled A + B reactions: role of mobility in forming compact clusters
We investigate the A + B = 0 bimolecular chemical reaction taking place in low-dimensional spaces when the mobilities of the two reacting species are not equal. While the case of different reactant mobilities ...
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Protocol
Hydrogen Peroxide (H2O2) Detection with Nanoprobes for Biological Applications: A Mini-review
Hydrogen peroxide (H2O2) is an important member of the reactive oxygen species, playing various roles in biology and medicine. The conventional detection methods for H2O2 are often restricted by their limited sen...
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Article
Checking out the insides of cells
A nanowire attached to an optical fibre can deliver payloads or light into specific compartments within a living cell, and also detect optical signals from subcellular regions with high spatial resolution.
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Chapter
Targeted, Multifunctional Hydrogel Nanoparticles for Imaging and Treatment of Cancer
Use of nanoparticles as a platform for carrying drugs, image contrast agents, or both has been considered to be a revolutionary approach for cancer diagnosis and therapy. Especially, hydrogel nanoparticles hav...
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Article
Targeted blue nanoparticles as photoacoustic contrast agent for brain tumor delineation
Distinguishing a tumor from non-neoplastic tissue is a challenging task during cancer surgery. Several attempts have been made to use visible or fluorescent agents to aid in the visualization of a tumor during...
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Article
Methylene blue covalently loaded polyacrylamide nanoparticles for enhanced tumor-targeted photodynamic therapy
The use of targeted nanoparticles (NPs) as a platform for loading photosensitizers enables selective accumulation of the photosensitizers in the tumor area, while maintaining their photodynamic therapy (PDT) e...
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Article
Observation of Laser Speckle Effects in an Elementary Chemical Reaction
An experimental demonstration is shown for non-classical reaction kinetics in a homogeneous system with an elementary reaction, A+B→C. Sensitivity to the initial distribution of reactants is observed, along wi...
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Article
Studies of Temperature-Dependent Excimer-Monomer Conversion in Dendrimeric Antenna Supermolecules by Fluorescence Spectroscopy
Phenylacetylene (PA) dendrimer labeled with perylene (See Fig 1) is discovered to exhibit temperature-dependent emission spectra in certain organic solvents over the temperature range of 20-65°C. The monomer s...
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Chapter
A Technical Description of the Brain Tumor Window Model: An In Vivo Model for the Evaluation of Intraoperative Contrast Agents
The evaluation of candidate optical contrast agents for brain tumor delineation in ex vivo models may not accurately predict their activity in vivo. This study describes an in vivo model system designed to ass...
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Protocol
Polymeric Nanoparticles for Photodynamic Therapy
Photodynamic therapy is a relatively new clinical therapeutic modality that is based on three key components: photosensitizer, light, and molecular oxygen. Nanoparticles, especially targeted ones, have recentl...
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Article
Multifunctional Nanoparticles for Targeted Imaging and Therapy of Cancer
The idea of making biocompatible multifunctional nanoparticles, combining therapy, imaging and targeting, was aimed at cancer from the start a dozen years ago. This presentation will emphasize targeted therano...
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Article
Catalysis without a catalyst
Can two identical reactors with the same concentrations, under identical physical conditions, have reaction rates that differ by a factor of a thousand? A study now shows that, although not true in uncrowded e...
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Article
Fabrication of Nanoparticles and Microspheres with Uniform Magnetic Half-Shells
We report a method for fabricating, anisotropically designed, multiphasic nano-particles with uniform magnetic half-shells. Cobalt layers were deposited onto commercially made non-magnetic polystyrene nanosphe...
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Chapter
Fluorescent Pebble Nano-Sensors and Nanoexplorers for Real-Time Intracellular and Biomedical Applications
PEBBLEs (Probes Encapsulated By Biologically Localized Embedding) are sub-micron sized optical sensors specifically designed for minimally invasive analyte monitoring in viable, single cells with applications ...
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Article
Anomalous Kinetics of Depletion Zone Growth with One-Dimensional Geometry: Photobleaching Experiments and Simulations
We studied the kinetics of a diffusion-limited trap** reaction A + T → T in an effective one-dimensional geometry by experiments, supported by simulation calculations. The experiments are based on the photob...
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Article
Dimensional Crossover in the Growth of Depletion Zone in a Rectangular Capillary: Experiments and Monte Carlo Simulations
The diffusion-limited kinetics of the growth of depletion zone around a static point trap in a thin, long stripe geometry was studied using a laser photobleaching experiment of fluorescein dye inside a rectang...
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Article
Characterization and Applications of Modulated Optical Nanoprobes (MOONs)
Modulated optical nanoprobes (MOONs) are microscopic (spherical and aspherical) particles designed to emit different fluxes of light in a manner that depends on particle orientation. When particle orientation ...
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Article
Optochemical Nanosensors and Subcellular Applications in Living Cells
What may be the smallest anthropogenic devices to date, spherical sensors (wireless and fiberless) with radii as small as 10 nm have been produced. This class of optochemical PEBBLE (Probe Encapsulated By Bio...
