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Article
Serum Survivin in Oral Submucosal Fibrosis and Squamous Cell Carcinoma
Survivin, an inhibitor of apoptosis protein is a biomarker of significance in prognostication of many malignancies. In the current study we investigated the serum survivin levels in patients with oral submucos...
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Article
Open AccessAn integrative gene expression signature analysis identifies CMS4 KRAS-mutated colorectal cancers sensitive to combined MEK and SRC targeted therapy
Over half of colorectal cancers (CRCs) are hard-wired to RAS/RAF/MEK/ERK pathway oncogenic signaling. However, the promise of targeted therapeutic inhibitors, has been tempered by disappointing clinical activi...
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Article
Open AccessPatients’ satisfaction with long-acting injectable somatostatin analog therapy for neuroendocrine tumors
Long-acting somatostatin analogs (LA SSAs) are approved and recommended for the treatment of patients with advanced neuroendocrine tumors (NETs). Given the long duration of therapy and differences in administr...
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Article
Open AccessDifferential methylation of G-protein coupled receptor signaling genes in gastrointestinal neuroendocrine tumors
Neuroendocrine tumors (NETs) of the small intestine undergo large chromosomal and methylation changes. The objective of this study was to identify methylation differences in NETs and consider how the different...
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Article
Cetuximab in Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Ovarian Cancer Without KRAS, NRAS, or BRAF Mutations: Results from the Targeted Agent and Profiling Utilization Registry (TAPUR) Study
The Targeted Agent and Profiling Utilization Registry (TAPUR) Study, a phase II basket study, evaluates anti-tumor activity of commercially available targeted agents in patients with advanced cancers harboring...
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Article
Low-Grade Fibromyxoid Sarcoma of the External Auditory Canal: A Rare Pathology and Unusual Location
Low-grade fibromyxoid sarcoma (LGFMS) is an enigmatic soft tissue tumor. It frequently presents as a deeply seated mass in the proximal extremities and trunk. Superficial LGFMSs of the head and neck are exceed...
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Article
Systemic amyloidosis masquerading as iron deficiency anemia
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Article
Apparent heparin resistance in a patient with infective endocarditis secondary to elevated factor VIII levels
Heparin resistance (HR) is defined as increasing requirements of heparin to maintain a therapeutic activated partial thromboplastin time (aPTT). It is commonly associated with antithrombin deficiency, increase...
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Article
Hemodynamic collapse following bilateral knee arthroplasty: a mysterious case
Severe hemodynamic collapse after knee surgery from bilateral adrenal hemorrhages is rare. Even rarer is it occurring from adrenal hemorrhage as a complication of heparin induced thrombocytopenia. Due to lack ...
