10 Result(s)

Article

Tumor-B-cell interactions promote isotype switching to an immunosuppressive IgG4 antibody response through upregulation of IL-10 in triple negative breast cancers

Triple negative breast cancer (TNBC) is an aggressive breast cancer for which there is currently no targeted therapy. Tumor-infiltrating B-cells (TIB) have been observed in tumor tissues of TNBC patients, but ...

Nicole J. Toney, Lynn M. Opdenaker, Kader Cicek… in Journal of Translational Medicine (2022)

Article

Retraction Note: IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance

Kumar Sachin Singh, Rishabh Sharma, Poli Adi Narayana Reddy, Prashanthi Vonteddu… in Nature (2021)

Article

Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy

Anti-PD-1 therapy is used as a front-line treatment for many cancers, but mechanistic insight into this therapy resistance is still lacking. Here we generate a humanized (Hu)-mouse melanoma model by injecting ...

Rajasekharan Somasundaram, Thomas Connelly, Robin Choi… in Nature Communications (2021)

Article

Pre-clinical modeling of cutaneous melanoma

Metastatic melanoma is challenging to manage. Although targeted- and immune therapies have extended survival, most patients experience therapy resistance. The adaptability of melanoma cells in nutrient- and th...

Vito W. Rebecca, Rajasekharan Somasundaram, Meenhard Herlyn in Nature Communications (2020)

Article

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. Current theories on regulation of inflammation center on anti-tumor T cell responses. Here we show that tumor as...

Johannes Griss, Wolfgang Bauer, Christine Wagner, Martin Simon… in Nature Communications (2019)

Article

Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

In melanoma, therapies with inhibitors to oncogenic BRAF^V600E are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of ...

Rajasekharan Somasundaram, Gao Zhang, Mizuho Fukunaga-Kalabis… in Nature Communications (2017)

Article

In vitro migration of cytotoxic T lymphocyte derived from a colon carcinoma patient is dependent on CCL2 and CCR2

Infiltration of colorectal carcinomas (CRC) with T-cells has been associated with good prognosis. There are some indications that chemokines could be involved in T-cell infiltration of tumors. Selective modula...

Klara Berencsi, Pyapalli Rani, Tianqian Zhang… in Journal of Translational Medicine (2011)

Article

CD8⁺, HLA-unrestricted, cytotoxic T-lymphocyte line against malignant melanoma

A CD8⁺ cytotoxic T lymphocyte (CTL) line was derived from the peripheral blood mononuclear cells of a patient with primary melanoma. The CD8⁺ CTL line specifically lysed the autologous primary melanoma cells and ...

Rajasekharan Somasundaram, Laura Caputo, DuPont Guerry… in Journal of Translational Medicine (2005)

Article

Cancer vaccines: single-epitope anti-idiotype vaccine versus multiple-epitope antigen vaccine

In this study, we compared the immunogenicity and tumor-protective activity of anti-idiotypic antibodies mimicking a single tumor-associated epitope and tumor-associated antigen expressing multiple potentiall...

Haruhiko Maruyama, Jan Zaloudik, Wei** Li… in Cancer Immunology, Immunotherapy (2000)

Article

Anti-idiotype cancer vaccines: past and future

 Anti-idiotypic antibodies (Ab2) binding to the antigen-combining site of antitumor antibodies (Ab1) can induce anti-anti-idiotypic antibodies (Ab3) that specifically bind to the tumor antigen recognized by Ab...

D. Herlyn, Rajasekharan Somasundaram, Wei** Li… in Cancer Immunology, Immunotherapy (1996)