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Article
Tuning inflammation and immunity by chemokine sequestration: decoys and more
Chemokines are small, secreted proteins with leukocyte chemoattractant and cytokine-like activities that are mediated by a distinct subfamily of G-protein-coup...
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Chapter
Chemokine Decoy Receptors: Structure–Function and Biological Properties
Chemokines induce cell migration through the activation of a distinct family of structurally related heterotrimeric G protein-coupled receptors (GPCR). Over the last few years, several receptors in this family...
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Protocol
Cancer and Chemokines
Chemokines are a large family of secreted cytokines whose main function is to mediate leukocyte directional migration. Most cancers contain chemokines and express chemokine receptors as a consequence of the ac...
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Article
Atypical matters in myeloid differentiation
Chemokines are important components of the hematopoietic niche. The atypical chemokine receptor 1 (ACKR1), expressed on erythrocyte precursors, regulates myeloid differentiation.
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Article
Open AccessACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity
Atypical chemokine receptors (ACKRs) are regulators of leukocyte traffic, inflammation, and immunity. ACKR2 is a scavenger for most inflammatory CC chemokines and is a negative regulator of inflammation. Here ...
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Article
Neutrophil diversity and plasticity in tumour progression and therapy
Neutrophils play a key role in defence against infection and in the activation and regulation of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have emerged as an important compo...
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Chapter
The Evolving Landscape of Monocyte/Macrophage System in Glioma
Glioma is one of the most common types of primary brain tumors in adults, highly malignant and resistant to conventional treatments. Glioma-associated macrophages (GAMs) represent the major immune cell populat...
