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Article
Open AccessA combination of a cell penetrating peptide and a protein translation inhibitor kills metastatic breast cancer cells
Cell Penetrating Peptides (CPPs) are promising anticancer and antimicrobial drugs. We recently reported that a peptide derived from the human mitochondrial/ER membrane-anchored NEET protein, Nutrient Autophagy...
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Article
Open AccessAn anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters
Elevated levels of mitochondrial iron and reactive oxygen species (ROS) accompany the progression of diabetes, negatively impacting insulin production and secretion from pancreatic cells. In search for a tool ...
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Article
Open AccessThe two redox states of the human NEET proteins’ [2Fe–2S] clusters
The NEET proteins constitute a unique class of [2Fe–2S] proteins. The metal ions bind to three cysteines and one histidine. The proteins’ clusters exist in two redox states; the oxidized protein (containing tw...
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Article
Open AccessIntegration of photocatalytic and dark-operating catalytic biomimetic transformations through DNA-based constitutional dynamic networks
Nucleic acid-based constitutional dynamic networks (CDNs) have recently emerged as versatile tools to control a variety of catalytic processes. A key challenge in the application of these systems is achieving ...
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Article
Open AccessThe cisd gene family regulates physiological germline apoptosis through ced-13 and the canonical cell death pathway in Caenorhabditis elegans
Programmed cell death, which occurs through a conserved core molecular pathway, is important for fundamental developmental and homeostatic processes. The human iron–sulfur binding protein NAF-1/CISD2 binds to ...
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Article
Open AccessThe unique fold and lability of the [2Fe-2S] clusters of NEET proteins mediate their key functions in health and disease
NEET proteins comprise a new class of [2Fe-2S] cluster proteins. In human, three genes encode for NEET proteins: cisd1 encodes mitoNEET (mNT), cisd2 encodes the Nutrient-deprivation autophagy factor-1 (NAF-1) and...
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Article
Open AccessPhylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin
The iron-sulfur (2Fe-2S) binding motif CDGSH appears in many important plant and animal proteins that regulate iron and reactive oxygen metabolism. In human it is found in CISD1-3 proteins involved in diabetes...
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Article
Open AccessPhylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates
NEET proteins belong to a unique family of iron-sulfur proteins in which the 2Fe-2S cluster is coordinated by a CDGSH domain that is followed by the “NEET” motif. They are involved in the regulation of iron an...
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Article
Correction: Corrigendum: Assembly of photo-bioelectrochemical cells using photosystem I-functionalized electrodes
Nature Energy 1, 15021 (2016); published 18 January 2016; corrected 28 January 2016. In the version of this Article originally published, an author's name contained a typographical error and should have read S...
