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Article
Nanocarrier – Mediated Salinomycin Delivery Induces Apoptosis and Alters EMT Phenomenon in Prostate Adenocarcinoma
Salinomycin (Sal) has been recently discovered as a novel chemotherapeutic agent against various cancers including prostate cancer which is one of the most commonly diagnosed cancers affecting male populations...
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Article
Trends in Formulation Approaches for Sustained Drug Delivery to the Posterior Segment of the Eye
The eye, an intricate organ comprising physical and physiological barriers, poses a significant challenge for ophthalmic physicians seeking to treat serious ocular diseases affecting the posterior segment, suc...
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Article
UHPLC Method for Quantification of Bioactive Components in Fenugreek Herbal Preparations
Trigonella foenum-graecum L., Fabaceae, also known as fenugreek, is a popular herb commonly used as a spice, flavoring, and medicinal agent. It is enriched with bioactive components namely pinitol, 4-hydroxy isol...
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Article
Mycobacterium tuberculosis survival and biofilm formation studies: effect of d-amino acids, d-cycloserine and its components
d-amino acids play an important role in cell wall peptidoglycan biosynthesis. Mycobacterium tuberculosis d-amino acid oxidase deletion led to reduced biofilm-forming ability. Other recent studies also suggest tha...
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Article
Pharmacokinetics, metabolism, bioavailability, tissue distribution and excretion studies of 16α-hydroxycleroda-3, 13(14) Z -dien-15, 16-olide—a novel HMG-CoA reductase inhibitor
The present study was designed to investigate the oral bioavailability, metabolism, tissue disposition and excretion of 16α-hydroxycleroda-3, 13(14) Z -dien-15, 16-olide (4655K-09), a novel HMG-CoA reductase i...
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Article
Pharmacokinetic-pharmacodynamic modeling of the antihypertensive interaction between azilsartan medoxomil and chlorthalidone in spontaneously hypertensive rats
A pharmacokinetic-pharmacodynamic (PK-PD) model was developed to describe the time course of blood pressure following oral administration of azilsartan medoxomil (AZM) and/or chlorthalidone (CLT) in spontaneou...
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Article
Erratum to: LC–MS Method for Determination of Amphotericin B in Rabbit Tears and Its Application to Ocular Pharmacokinetic Study
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Article
LC–MS Method for Determination of Amphotericin B in Rabbit Tears and Its Application to Ocular Pharmacokinetic Study
A rapid and sensitive LC–MS–MS method was developed for the quantification of amphotericin B in rabbit tears using natamycin as internal standard. The analyte and internal standard were extracted from the tear...
