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Article
Ca2+-activated K+ channels in human smooth muscle cells of coronary atherosclerotic plaques and coronary media segments
The behavior of Ca2+-activated K+ channels of large conductance (BKCa) in smooth muscle cells, which were obtained from atherosclerotic plaque material (SMCP) and from media segments (SMCM) of human coronary arte...
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Chapter
Differences in growth behaviour of human vascular smooth muscle cells in culture
In order to compare in vitro growth behaviour of human smooth muscle cells (SMC), obtained from different vessels, cells were isolated from small pieces of femoral-, internal mammary-, renal-, thoracal-, steno...
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Chapter
Analysis of lateral mobility of molecules in the membrane of coronary plaque cells by measuring fluorescence recovery after photobleaching
Molecular transport mechanisms in membranes of smooth muscle cells (SMC) are of interest for a better understanding of atherogenesis. Atherosclerotic plaque material from the coronary arteries of 5 patients wa...
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Chapter
The effect of cytostatic agents on plaque cells of human atherosclerotic lesions: Dose reduction by a combined drug regime?
Restenosis remains an unsolved problem in the therapeutic use of angioplasty catheters. The migration and proliferation of smooth muscle cells from the media into the subendothelial space are key events in the...
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Chapter
Lipoprotein levels following oral fat intake in patients with coronary heart disease
Triglyceride-rich lipoproteins are thought to be associated with an accelerated development of arteriosclerosis. The influence of an oral fat load of 100 g fat on blood lipids and lipoproteins has been investi...
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Chapter
Growth pattern of human endothelial cells after compression with 3 bar in vitro
Destruction of endothelial cells (EC) seems to be a key factor in the development of restenosis after angioplasty. In this study cell growth of EC was examined for 11 days after compression with 3 bar/cm2 in vitr...
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Chapter
Migration and proliferation of human plaque cells in vitro: effect of Dipyridamole?
Migration and proliferation of smooth muscle cells (SMC) from the media into the subendothelial space have been recognized as essential steps in the development of atherosclerotic plaques. Plaque material of p...
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Chapter
Increased growth rates of percutaneously and surgically extracted plaque cells from human restenosing tissue in vitro
Migration and proliferation of smooth muscle cells (SMC) from the media into the subendothelial space are key events in the early stages of athero-genesis [1]. Thus SMC are, besides macrophages, the main cell ...
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Article
In vitro growth characteristics of human atherosclerotic plaque cells: Comparison of cells from primary stenosing and restenosing lesions of peripheral and coronary arteries
Cell size distribution and growth rates were studied in vitro in human plaque cells from advanced primary stenosing and fresh restenosing lesions of peripheral and coronary arteries. Cells were isolated either...
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Chapter
Vergleich der Wachstumsraten von glatten Muskelzellen aus primär- und restenosierendem Plaquematerial des Menschen und der Effekt von Azetylsalizylsäure in vitro
Die Migration und Proliferation von glatten Gefäßmuskelzellen (SMC) aus der Media in den subendothelialen Raum ist eines der Schlüsselereignisse in der Frühphase der Atherogenese [3, 6, 15, 16, 17]. Mit histol...
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Article
Selective percutaneous “biopsy” of atheromatous plaque tissue for cell culture
The combination of percutaneous atherectomy and angioscopy enabled a selective “biopsy” of protruding atheromatous plaque material from 11 patients with arterial occlusive disease. The removed specimens were c...
