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Article
Open AccessThe role of the cancer stem cell marker CD271 in DNA damage response and drug resistance of melanoma cells
Several lines of evidence have suggested that stemness and acquired resistance to targeted inhibitors or chemotherapeutics are mechanistically linked. Here we observed high cell surface and total levels of ner...
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Article
Open AccessUncoupling of EGFR–RAS signaling and nuclear localization of YBX1 in colorectal cancer
The transcription factor YBX1 can act as a mediator of signals transmitted via the EGFR–RAS–MAPK axis. YBX1 expression has been associated with tumor progression and prognosis in multiple types of cancer. Immu...
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Article
Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity
Colon cancer cells frequently carry mutations that activate the β-catenin and mitogen-activated protein kinase (MAPK) signaling cascades. Yet how oncogenic alterations interact to control cellular hierarchies ...
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Article
Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation
Silencing of gene expression by methylation of CpG islands in regulatory elements is frequently observed in cancer. However, an influence of the most common oncogenic signalling pathways onto DNA methylation h...
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Article
The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1
Multidrug resistance may be achieved by the activation of membrane transporters, detoxification, alterations in DNA repair or failure in apoptotic pathways. Recent data have suggested an involvement of mitogen...