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Article
Synphilin-1 isoforms in Parkinson’s disease: regulation by phosphorylation and ubiquitylation
Parkinson’s disease (PD) is characterized by the death of dopaminergic neurons and the presence of Lewy bodies in the substantia nigra pars compacta. The mechanisms involved in the death of neurons as well as ...
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Article
Determinants of pantropism of the F1-R mutant of Sendai virus: specific mutations involved are in the F and M genes
Mutations in the fusion, F, protein of Sendai virus resulting in increased cleavability by ubiquitous host protease(s), and mutations in the matrix, M, protein resulting in bipolar budding, are both important ...
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Article
The 3′ untranslated regions of chloroplast genes inChlamydomonas reinhardtii do not serve as efficient transcriptional terminators
A general characteristic of the 3′ untranslated regions of plastid mRNAs is an inverted repeat sequence that can fold into a stem-loop structure. These stem-loops are superficially similar to structures involv...
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Article
Pathogenicity of influenza A/Seal/Mass/1/80 virus mutants for mammalian species
Increases in infectiousness, neurotropism and virulence were found in a laboratory variant of influenza A/Seal/Massachussets/1/80 (H7N7) virus having a highly cleavable hemagglutinin. Sequential passage from h...
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Chapter
Natural and Experimental Borna Disease in Animals
Borna disease (BD) is a transmissible, progressive polioencephalomyelitis of horses and sheep, which are the main natural hosts. It occurs sporadically in endemic areas of Germany and Switzerland, while its pr...
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Article
Demonstration of Borna disease virus-specific RNA in secretions of naturally infected horses by the polymerase chain reaction
The presence of Borna disease virus (BDV)-specific RNA was traced by the reverse transcriptase-polymerase chain reaction in conjunctival fluid, nasal secretions and saliva of horses which were seropositive but...
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Chapter and Conference Paper
Borna disease virus: nature of the etiologic agent and significance of infection in man
This review presents data on the characterization of Borna disease virus (BDV) and its potential as a possible causative agent in humans. The isolation of (i) BDV-specific cDNA clones that encode various BDV-s...
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Chapter and Conference Paper
Pathogenesis of Borna disease
Borna disease represents a unique model of a virus-induced immunological disease of the brain. Naturally occurring in horses and sheep, the mechanisms of pathogenesis have been studied in experimental animals,...
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Article
Significance of basolateral domain of polarized MDCK cells for Sendai virus-induced cell fusion
Fusion (fusion from within) of polarized MDCK monolayer cells grown on porous membranes was examined after infection with Sendai viruses. Wild-type virus, that buds at the apical membrane domain, did not induc...
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Article
Comparison of hemagglutinating, receptor-destroying, and acetylesterase activities of avirulent and virulent bovine coronavirus strains
Hemagglutinating and acetylesterase functions as well as the 124 kDa glycoprotein were present in the highly cell-culture adapted, avirulent bovine coronavirus strain BCV-L9, in the Norden vaccine strain deriv...
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Article
Borna disease, a possible hazard for man?
Evidence is presented that Borna disease (BD) virus, which is known to cause encephalopathy in horses, sheep, and a broad range of experimental animals, or a related agent, can infect man and may induce mental...
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Article
Immunocytochemical study of the subcommissural organ of rats with induced postnatal hydrocephalus
The subcommissural organ (SCO)-Reissner's fiber (RF) complex of rats suffering from postnatal hydrocephalus was investigated immunocytochemically (peroxidase-antiperoxidase technique) by use of an antiserum ag...
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Article
Determination of immune cells and expression of major histocompatibility complex class II antigen in encephalitic lesions of experimental Borna disease
After intracerebral infection with Borna disease virus adult Lewis rats develop a virus-induced immunopathological reaction resulting in severe neurological symptoms and a non-purulent meningoencephalitis. The...
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Article
Comparison of protective effects of serum antibody on respiratory and systemic infection of Sendai virus in mice
The protective effects of the passive administration of convalescent serum from mice infected with Sendai virus were evaluated in mice challenged intranasally with wild-type and a pantropic variant (F1-R) of S...
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Article
Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats
In this study it has been shown that infection of mother rats by Borna disease virus (BDV) from infected newborns led to a fatal disease. This differed both in clinical symptoms and in histological alterations...
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Chapter
Infektion mit dem Virus der Bornaschen Krankheit als Ursache von psychiatrisch relevanten Erkrankungen des Menschen?
Die Bornasche Krankheit ist eine seltene, endemisch auftretende Meningoenzephalitis bei Pferd und Schaf. Bei diesen führt sie nach schweren Lähmungen meist zum Tode. Histopathologisch findet man in der grauen ...
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Chapter and Conference Paper
Viral Glycoproteins as Determinants of Pathogenicity
Many viruses possess a lipid-containing envelope which is a simple biological membrane surrounding the viral genome and accessory proteins. Among the general features of membrane structure shared by all of the...
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Article
Protective effect of antibodies to two viral envelope glycoproteins on lethal infection with Newcastle disease virus
The protective effect of humoral immunity against lethal infection of chickens with Newcastle disease virus was studied.
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Article
Aggravation of pathogenicity of an avian influenza virus by adaptation to quails
Influenza virus A/turkey/Ontario/7732/66 (H 5 N 9), which is highly pathogenic to chickens, is nonpathogenic to quails. After intratracheal or intramuscular inoculation of quails, virus replication was limited...
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Article
Role of Staphylococcus protease in the development of influenza pneumonia
In influenza the combined virus–bacterial pneumonia is approximately three times more common than primary viral pneumonia1. The bacteria most commonly involved are Staphylococcus aureus, Streptococcus pneumoniae ...
