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Article
PLASMA LH, FSH AND TESTOSTERONE RESPONSE TO LH-RH IN B0YS WITH COMPENSATORY TESTICULAR HYPERTROPHY
The plasma LH, FSH and testosterone response to LH-RH was studied in 12 boys with compensatory testicular hypertrophy (CTH) and normal puberty and in a matched control group with normal testicular development....
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Article
Sex-specific sensitivity of the hypothalamic pituitary axis to estradiol benzoate in normal children
The influence of i.m. estradiol benz. (EB)(10-15 mcg/kg) on basal plasma E2, LH and FSH and their response to LRH (50 mcg/m2 i. v.) in normal children was studied. In all pubertal (n=10), early (n=15) and late pu...
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Article
Classification of patients with GH deficiency (GHD) according to the response to GH-RH
Synthetic GH-RH-1-44 was administered in a dose of 1 mcg/1 Kg to 3 normal adolescents with short stature and to 17 patients with GHD (hGH response to ITT and clonidine < 2 ng/ml). In the normal subjects the pe...
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Article
Enhanced hGH pituitary secretion rate associated with somatomedin deficiency as manifested in Laron type dwarfism (LTD)
In 3 patients with LTD and 8 normal subjects the following parameters were determined:
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Article
40 hGH RESPONSE TO GH-RH 1–44 IN OBESITY OF VARIOUS ETIOLOGIES
Fourteen juveniles with obesity were tested with i.v. GH-RH 1-44 (1 mcg/kg). Seven had simple obesity and in the other 7 the obesity was associated with the following syndromes: Prader-Willi (n=4); Laurence Mo...
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Article
24-HOUR GH SECRETION PATTERN IN FAMILIAL TALL STATURE
GH secretion was measured by 30 mins. sampling over 24 hrs (using a Cormed pump) in 3 tall girls (aged 12, 14 & 16 yrs), belonging to a family of tall stature (4 of 7 sibs & parents were above 90th centile). I...
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Article
GROWTH HORMONE (GH) IS NORMAL IN GIRLS WITH PRECOCIOUS PUBERTY DURING SUPPRESSIVE THERAPY WITH LH-RH ANALOGUE (D-TRP-6-LH-RH)
The inhibition of gonadotropin secretion in children with central precocious puberty treated with LH-RH analogues results in suppression of the pubertal development, including growth velocity. In some patients...
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Article
hGH RESPONSE TO REPEATED GH-RH 1-44 ADMINISTRATION IN HYPOPITUITARY CHILDREN
The aim of the present investigation was to determine the effectiveness of 1 daily s.c. injection for 5 consecutive days of GHRH 1-44 (1 mcg/Kg) on the plasma hGH response to an i.v. bolus of GH-RH 1-44 (1 mcg...
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Article
ADVANTAGES OF THE hGH 24hr SECRETORY PATTERN IN DISTINGUISHING GROWTH DISORDERS
We performed a comparative study of 24hr hGH secretion vs. stimulation tests in 48 pts. vided into 5 groups: GR 1 - organic CNS disorder, no hGH; GR 2 - partial GH def., low hGH; GR 3 - short stature, normal h...
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Article
42 SERUM GROWTH HORMONE BINDING PROTEIN (GH-BP) IN PRE-PUBERTAL CHILDREN IS CORRELATED WITH HEIGHT
Recently serum GH-BP has been shown to have identical N-terminal amino acid sequence as the tissue hGH receptor. Serum hGH levels and the specific binding activity of GH-BP (expressed as % of GH-BP activity of...
