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Article
Open Accessc-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cells
Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies with an overall life expectancy of 6 months despite current therapies. NF-κB signalling has been shown to be critical for this ...
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Article
Open AccessBase-pair resolution DNA methylome of the EBV-positive Endemic Burkitt lymphoma cell line DAUDI determined by SOLiD bisulfite-sequencing
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Article
Open AccessIdentification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is a malignant disease of the white blood cells. The etiology of ALL is believed to be multifactorial and likely to involve an interplay of environmental and genetic variable...
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Article
Open AccessIsomer-specific effects of CLA on gene expression in human adipose tissue depending on PPARγ2 P12A polymorphism: a double blind, randomized, controlled cross-over study
Peroxisome proliferator-activated receptor (PPAR)γ is a key regulator in adipose tissue. The rare variant Pro12Ala of PPARγ2 is associated with a decreased risk of insulin resistance. Being dietary PPARγ ligan...
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Article
From model cell line to in vivo gene expression: disease-related intestinal gene expression in IBD
Crohn's disease (CD) and ulcerative colitis (UC) are subforms of inflammatory bowel diseases (IBD). Genetic and environmental factors influencing the onset and course of the diseases have been recently identif...
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Article
Systematic expression profiling of innate immune genes defines a complex pattern of immunosenescence in peripheral and intestinal leukocytes
Immunosenescence is characterized by a quantitative decline of adequate immune responses, which renders the elderly individual particularly susceptible to bacterial, viral and fungal pathogens. Whereas changes...
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Article
Erratum: Acquired chemoresistance in pancreatic carcinoma cells: induced secretion of IL-1β and NO lead to inactivation of caspases
Correction to: Oncogene (2006) 25, 3973–3981. doi:10.1038/sj.onc.1209423 Since publication of the above manuscript, the authors have identified errors in Figure 6b and c. The revised version of the figure is g...
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Article
Acquired chemoresistance in pancreatic carcinoma cells: induced secretion of IL-1β and NO lead to inactivation of caspases
Pancreatic cancer exhibits profound chemoresistance resulting either from pre-existing (intrinsic) mechanisms, or from anticancer drug treatment itself (acquired chemoresistance). To identify molecular alterat...
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Article
Some effects of long-term ozone fumigations on Norway spruce
Potted cuttings of a 12-year-old, and grafts of an 80-year-old, Norway spruce (Picea abies (L.) Karst.) were subjected to 100 or 300 μg O3·m−3 for 1215 h (45 h of daylight per week) during the growing season of 1...
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Article
The influence of a fall fumigation with ozone on the stomatal behavior of spruce and fir
Clonal stock (grafts of 15-, 50-, and 100-year-old trees) of spruce (Picea abies (L.) Karst.) and fir (Abies alba Mill.) was exposed either to 150 ppb ozone (∼300 μgm-3) during 9 daylight hours or to carbon-filte...
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Article
Net photosynthesis and transpiration of Pinus montana on east and north facing slopes at alpine timberline
Potted Pinus montana seedlings, age 4 years, transplanted on adjacent east and north facing slopes 25 m apart at alpine timberline (2,020 m a.s.l.) were measured for net photosynthesis and transpiration under amb...
