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Article
Melatonin inhibits Gram-negative pathogens by targeting citrate synthase
Bacterial infections caused by Gram-negative pathogens represent a growing burden for public health worldwide. Despite the urgent need for new antibiotics that effectively fight against pathogenic bacteria, ve...
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Article
Melatonin and the electron transport chain
Melatonin protects the electron transport chain (ETC) in multiple ways. It reduces levels of ·NO by downregulating inducible and inhibiting neuronal nitric oxide synthases (iNOS, nNOS), thereby preventing exce...
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Chapter
Deacceleration of Brain Aging by Melatonin
Melatonin counteracts several pathophysiological processes that promote brain aging. A central feature of these aging-accelerating changes is low-grade brain inflammation, which may progressively aggravate, es...
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Article
Antioxidant activity in Spalax ehrenbergi: a possible adaptation to underground stress
The blind subterranean mole rat Spalax ehrenbergi superspecies has evolved adaptive strategies to cope with underground stress. Hypoxia is known to stimulate reactive oxygen species generation; however, mechanism...
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Chapter
An Ancient Cellular Mechanism in the Tension Field between Energy Requirements and Destruction Avoidance
Circadian rhythmicity is a fundamental biological phenomenon of almost ubiquitous importance. This kind of an endogenous, innate oscillation with a period length of about a day is present in the majority of or...
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Chapter
Circadian Rhythms and Oxidative Stress in Non-vertebrate Organisms
Several lines of evidence suggest that the circadian organization of living beings is important for avoiding excessive oxidative stress under physiological conditions. In the dinoflagellate Gonyaulax polyedra, ac...
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Article
The vertebrate pineal hormone melatonin is produced by the brown alga Pterygophora californica and mimics dark effects on growth rate in the light
Melatonin, a methoxylated indoleamine, plays a role as a mediator of darkness in animals as well as in the unicellular alga Gonyaulax polyedra Stein and was recently detected in higher plants. We report on the fi...