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    Article

    Melatonin inhibits Gram-negative pathogens by targeting citrate synthase

    Bacterial infections caused by Gram-negative pathogens represent a growing burden for public health worldwide. Despite the urgent need for new antibiotics that effectively fight against pathogenic bacteria, ve...

    Fang He, Yuan Liu, Pan Li, **aoyan Wu, Yaoyao **a… in Science China Life Sciences (2022)

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    Article

    Melatonin and the electron transport chain

    Melatonin protects the electron transport chain (ETC) in multiple ways. It reduces levels of ·NO by downregulating inducible and inhibiting neuronal nitric oxide synthases (iNOS, nNOS), thereby preventing exce...

    Rüdiger Hardeland in Cellular and Molecular Life Sciences (2017)

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    Chapter

    Deacceleration of Brain Aging by Melatonin

    Melatonin counteracts several pathophysiological processes that promote brain aging. A central feature of these aging-accelerating changes is low-grade brain inflammation, which may progressively aggravate, es...

    Rüdiger Hardeland in Inflammation, Aging, and Oxidative Stress (2016)

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    Article

    Antioxidant activity in Spalax ehrenbergi: a possible adaptation to underground stress

    The blind subterranean mole rat Spalax ehrenbergi superspecies has evolved adaptive strategies to cope with underground stress. Hypoxia is known to stimulate reactive oxygen species generation; however, mechanism...

    Beatriz Caballero, Cristina Tomás-Zapico… in Journal of Comparative Physiology A (2006)

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    Chapter

    An Ancient Cellular Mechanism in the Tension Field between Energy Requirements and Destruction Avoidance

    Circadian rhythmicity is a fundamental biological phenomenon of almost ubiquitous importance. This kind of an endogenous, innate oscillation with a period length of about a day is present in the majority of or...

    Rüdiger Hardeland in The Redox State and Circadian Rhythms (2000)

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    Chapter

    Circadian Rhythms and Oxidative Stress in Non-vertebrate Organisms

    Several lines of evidence suggest that the circadian organization of living beings is important for avoiding excessive oxidative stress under physiological conditions. In the dinoflagellate Gonyaulax polyedra, ac...

    Rüdiger Hardeland, Ana Coto-Montes… in The Redox State and Circadian Rhythms (2000)

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    Article

    The vertebrate pineal hormone melatonin is produced by the brown alga Pterygophora californica and mimics dark effects on growth rate in the light

    Melatonin, a methoxylated indoleamine, plays a role as a mediator of darkness in animals as well as in the unicellular alga Gonyaulax polyedra Stein and was recently detected in higher plants. We report on the fi...

    Birgit Fuhrberg, Ivonne Balzer, Rüdiger Hardeland, Astrid Werner, Klaus Lüning in Planta (1996)

  8. No Access

    Article

    Geschlechtsbedingte Unterschiede bei Tagesrhythmen von Insekten

    Sex-dependent differences in diuranl rhythms of insects concerning mainly phase and pattern are reviewed. As possible significant factors in the evolution of such differences are discussed: life span of the sp...

    Rüdiger Hardeland in Oecologia (1969)

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    Article

    Circadiane Rhythmik und Regulation von Enzymen des Tryptophan-Stoffwechsels in Rattenleber und -niere

    1. The activity of tryptophan pyrrolase shows a monophasic circadian rhythm. The increase in activity is due to ...

    Rüdiger Hardeland in Zeitschrift für vergleichende Physiologie (1969)