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  1. No Access

    Article

    Synthesis of [1,2-3H2]-polystyrene

    The synthesis of [1,2-3H2]-polystyrene consisted of a two step reaction. First catalytic tritium gas addition to phenylacetylene was used to prepare [1,2-3H2]-styrene and then it was polymerized to [1,2-3H2]-poly...

    Dezhu Wu, Qingwang Chen, Ginfu Li in Journal of Radioanalytical and Nuclear Chemistry (2003)

  2. No Access

    Article

    Isolation of a feather-degrading strain of bacterium from spider gut and the purification and identification of its three key enzymes

    A novel feather-degrading bacterium named CA-1 was isolated from the gut of the spider Chilobrachys guangxiensis, which degrades native whole chicken feathers within 20 h. The CA-1 was confirmed to belong to Sten...

    Fang Qu, Qingwang Chen, Yiying Ding, Zihao Liu, Yan Zhao in Molecular Biology Reports (2018)

  3. Article

    Open Access

    A comprehensive genomic and transcriptomic dataset of triple-negative breast cancers

    Molecular subty** of triple-negative breast cancer (TNBC) is essential for understanding the mechanisms and discovering actionable targets of this highly heterogeneous type of breast cancer. We previously pe...

    Qingwang Chen, Yaqing Liu, Yuechen Gao, Ruolan Zhang, Wanwan Hou in Scientific Data (2022)

  4. Article

    Open Access

    Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling

    Certified RNA reference materials are indispensable for assessing the reliability of RNA sequencing to detect intrinsically small biological differences in clinical settings, such as molecular subty** of dis...

    Ying Yu, Wanwan Hou, Yaqing Liu, Haiyan Wang, Lianhua Dong in Nature Biotechnology (2023)

  5. Article

    Open Access

    Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials

    Characterization and integration of the genome, epigenome, transcriptome, proteome and metabolome of different datasets is difficult owing to a lack of ground truth. Here we develop and characterize suites of ...

    Yuanting Zheng, Yaqing Liu, **gcheng Yang, Lianhua Dong, Rui Zhang in Nature Biotechnology (2023)

  6. Article

    Open Access

    Correcting batch effects in large-scale multiomics studies using a reference-material-based ratio method

    Batch effects are notoriously common technical variations in multiomics data and may result in misleading outcomes if uncorrected or over-corrected. A plethora of batch-effect correction algorithms are propose...

    Ying Yu, Naixin Zhang, Yuanbang Mai, Luyao Ren, Qiaochu Chen, Zehui Cao in Genome Biology (2023)

  7. Article

    Open Access

    Author Correction: Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling

    Ying Yu, Wanwan Hou, Yaqing Liu, Haiyan Wang, Lianhua Dong in Nature Biotechnology (2023)

  8. Article

    Open Access

    The Quartet Data Portal: integration of community-wide resources for multiomics quality control

    The Quartet Data Portal facilitates community access to well-characterized reference materials, reference datasets, and related resources established based on a family of four individuals with identical twins ...

    **gcheng Yang, Yaqing Liu, Jun Shang, Qiaochu Chen, Qingwang Chen in Genome Biology (2023)

  9. Article

    Open Access

    Extend the benchmarking indel set by manual review using the individual cell line sequencing data from the Sequencing Quality Control 2 (SEQC2) project

    Accurate indel calling plays an important role in precision medicine. A benchmarking indel set is essential for thoroughly evaluating the indel calling performance of bioinformatics pipelines. A reference samp...

    Binsheng Gong, Dan Li, Yifan Zhang, Rebecca Kusko, Samir Lababidi in Scientific Reports (2024)

  10. No Access

    Article

    Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities

    Molecular profiling guides precision treatment of breast cancer; however, Asian patients are underrepresented in publicly available large-scale studies. We established a comprehensive multiomics cohort of 773 ...

    Yi-Zhou Jiang, Ding Ma, ** **, Yi **ao, Ying Yu, **xiu Shi, Yi-Fan Zhou in Nature Cancer (2024)

  11. Article

    Open Access

    Plasma-Free Blood as a Potential Alternative to Whole Blood for Transcriptomic Analysis

    RNA sequencing (RNAseq) technology has become increasingly important in precision medicine and clinical diagnostics, and emerged as a powerful tool for identifying protein-coding genes, performing differential...

    Qingwang Chen, **aorou Guo, Haiyan Wang, Shanyue Sun, He Jiang, Peipei Zhang in Phenomics (2024)