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Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities
Molecular profiling guides precision treatment of breast cancer; however, Asian patients are underrepresented in publicly available large-scale studies. We established a comprehensive multiomics cohort of 773 ...
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Open AccessPlasma-Free Blood as a Potential Alternative to Whole Blood for Transcriptomic Analysis
RNA sequencing (RNAseq) technology has become increasingly important in precision medicine and clinical diagnostics, and emerged as a powerful tool for identifying protein-coding genes, performing differential...
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Open AccessExtend the benchmarking indel set by manual review using the individual cell line sequencing data from the Sequencing Quality Control 2 (SEQC2) project
Accurate indel calling plays an important role in precision medicine. A benchmarking indel set is essential for thoroughly evaluating the indel calling performance of bioinformatics pipelines. A reference samp...
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Open AccessThe Quartet Data Portal: integration of community-wide resources for multiomics quality control
The Quartet Data Portal facilitates community access to well-characterized reference materials, reference datasets, and related resources established based on a family of four individuals with identical twins ...
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Open AccessAuthor Correction: Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling
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Open AccessQuartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling
Certified RNA reference materials are indispensable for assessing the reliability of RNA sequencing to detect intrinsically small biological differences in clinical settings, such as molecular subty** of dis...
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Open AccessMulti-omics data integration using ratio-based quantitative profiling with Quartet reference materials
Characterization and integration of the genome, epigenome, transcriptome, proteome and metabolome of different datasets is difficult owing to a lack of ground truth. Here we develop and characterize suites of ...
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Open AccessCorrecting batch effects in large-scale multiomics studies using a reference-material-based ratio method
Batch effects are notoriously common technical variations in multiomics data and may result in misleading outcomes if uncorrected or over-corrected. A plethora of batch-effect correction algorithms are propose...
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Open AccessA comprehensive genomic and transcriptomic dataset of triple-negative breast cancers
Molecular subty** of triple-negative breast cancer (TNBC) is essential for understanding the mechanisms and discovering actionable targets of this highly heterogeneous type of breast cancer. We previously pe...
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Isolation of a feather-degrading strain of bacterium from spider gut and the purification and identification of its three key enzymes
A novel feather-degrading bacterium named CA-1 was isolated from the gut of the spider Chilobrachys guangxiensis, which degrades native whole chicken feathers within 20 h. The CA-1 was confirmed to belong to Sten...
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Synthesis of [1,2-3H2]-polystyrene
The synthesis of [1,2-3H2]-polystyrene consisted of a two step reaction. First catalytic tritium gas addition to phenylacetylene was used to prepare [1,2-3H2]-styrene and then it was polymerized to [1,2-3H2]-poly...