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Article
Open AccessDecoding cellular plasticity and niche regulation of limbal stem cells during corneal wound healing
Dysfunction or deficiency of corneal epithelium results in vision impairment or blindness in severe cases. The rapid and effective regeneration of corneal epithelial cells relies on the limbal stem cells (LSCs...
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Article
Open AccessCorrection: Sleep deprivation induces corneal endothelial dysfunction by downregulating Bmal1
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Article
Reconstruction of ocular surfaces with limbal stem cells supported by porous composite hydrogels
Stem cell-based therapy is a novel technique used to reconstruct the ocular surface of patients with limbal stem cell deficiency (LSCD). However, the reported stem cell therapies for LSCD are limited to two-di...
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Article
Open AccessSleep deprivation induces corneal endothelial dysfunction by downregulating Bmal1
Sleep deprivation (SD) is a common public health problem that contributes to various physiological disorders and increases the risk of ocular diseases. However, whether sleep loss can damage corneal endothelia...
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Article
Open AccessRapid reconstitution of ubiquitinated nucleosome using a non-denatured histone octamer ubiquitylation approach
Histone ubiquitination modification is emerging as a critical epigenetic mechanism involved in a range of biological processes. In vitro reconstitution of ubiquitinated nucleosomes is pivotal for elucidating t...
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Article
Multimodal data integration using machine learning to predict the risk of clear cell renal cancer metastasis: a retrospective multicentre study
To develop and validate a predictive combined model for metastasis in patients with clear cell renal cell carcinoma (ccRCC) by integrating multimodal data.
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Article
Open AccessCorrection to: The relationship between imaging features, therapeutic response, and overall survival in pediatric diffuse intrinsic pontine glioma
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Article
Friction Reduction of Aluminum Alloy Micro-arc Oxidation Coating by Filling Graphene Oxide
In this study, three kinds of micro-arc oxidation (MAO) coatings based on the 2A12 aluminum alloy were prepared with molybdenum disulfide (MoS2), tungsten disulfide (WS2), and graphene oxide (GO) in hexametaphosp...
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Article
Constrained least square progressive and iterative approximation (CLSPIA) for B-spline curve and surface fitting
Combining the Lagrange multiplier method, the Uzawa algorithm, and the least square progressive and iterative approximation (LSPIA), we proposed the constrained least square progressive and iterative approximatio...
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Article
Mechanical Behavior Based on Aggregates Microstructure of Ultra-high Performance Concrete
We developed ultra-high performance concrete (UHPC) incorporating mullite sand and brown corundum sand (BCS), and the quartz sand UHPC was utilized to prepare for comparison. The properties of compressive stre...
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Article
Surrounding rock instability mechanism for fault-crossing tunnels in water-rich soft rock
The stability assessment of a potential tunnel, especially a tunnel excavated under complicated geological conditions, is an essential task in tunnel design because it helps to determine the most suitable supp...
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Article
Open AccessEffective delivery of miR-150-5p with nucleus pulposus cell-specific nanoparticles attenuates intervertebral disc degeneration
The use of gene therapy to deliver microRNAs (miRNAs) has gradually translated to preclinical application for the treatment of intervertebral disc degeneration (IDD). However, the effects of miRNAs are hindere...
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Article
Different genetic profiles contribute to worse overall survival in patients with leptomeningeal metastases of non-small-cell lung cancer
To assess the genetic characteristics of central nervous system (CNS) metastases from non-small-cell lung cancer (NSCLC), we gathered the genetic profiles of brain metastases (BM) and leptomeningeal metastases...
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Article
Thermal and mechanical properties of recyclable epoxy asphalt vitrimers
Epoxy asphalt has been extensively utilized in the construction of long-span steel deck bridges. Due to its thermosetting nature, however, the end-of-life epoxy asphalt cannot be reclaimed as thermoplastic pol...
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Article
Open AccessSingle-cell and spatial transcriptomics reveal metastasis mechanism and microenvironment remodeling of lymph node in osteosarcoma
Osteosarcoma (OS) is the most common primary malignant bone tumor and is highly prone to metastasis. OS can metastasize to the lymph node (LN) through the lymphatics, and the metastasis of tumor cells reestabl...
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Article
Open AccessUnraveling transcriptomic signatures and dysregulated pathways in systemic lupus erythematosus across disease states
This study aims to elucidate the transcriptomic signatures and dysregulated pathways in patients with Systemic Lupus Erythematosus (SLE), with a particular focus on those persisting during disease remission.
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Article
Open AccessRapid and on-site wireless immunoassay of respiratory virus aerosols via hydrogel-modulated resonators
Rapid and accurate detection of respiratory virus aerosols is highlighted for virus surveillance and infection control. Here, we report a wireless immunoassay technology for fast (within 10 min), on-site (wire...
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Article
Open AccessThe relationship between imaging features, therapeutic response, and overall survival in pediatric diffuse intrinsic pontine glioma
We aimed to evaluate the relationship between imaging features, therapeutic responses (comparative cross-product and volumetric measurements), and overall survival (OS) in pediatric diffuse intrinsic pontine g...
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Article
Is Yang-Mills theory unitary in fractional spacetime dimensions?
We present concrete evidence that Yang-Mills theory exhibits non-unitarity in non-integer spacetime dimensions. This violation of unitarity stems from evanescent operators that, while vanishing in four dimensi...
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Article
Optimal Energy Efficiency Based High-speed Flying Control Method for Hydraulic Quadruped Robot
Herein, a control method based on the optimal energy efficiency of a hydraulic quadruped robot was proposed, which not only realizes the optimal energy efficiency of flying trot gait but also ensures the stabi...
