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Resurgence of pertussis: reasons and co** strategies
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Article
Fucosyltransferase 8 regulates adult neurogenesis and cognition of mice by modulating the Itga6-PI3K/Akt signaling pathway
Fucosyltransferase 8 (Fut8) and core fucosylation play critical roles in regulating various biological processes, including immune response, signal transduction, proteasomal degradation, and energy metabolism....
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Open AccessA nomogram for predicting hemorrhagic shock in pediatric patients with multiple trauma
The timely detection and management of hemorrhagic shock hold paramount importance in clinical practice. This study was designed to establish a nomogram that may facilitate early identification of hemorrhagic ...
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Open AccessSevere pediatric COVID-19: a review from the clinical and immunopathophysiological perspectives
Coronavirus disease 2019 (COVID-19) tends to have mild presentations in children. However, severe and critical cases do arise in the pediatric population with debilitating systemic impacts and can be fatal at ...
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Continuous age- and sex-specific reference ranges of liver enzymes in Chinese children and application in pediatric non-alcoholic fatty liver disease
Alanine aminotransferase (ALT) is widely used to screen patients with hepatic diseases. However, the current reference ranges (< 50 U/L) were developed by laboratories and have not been validated in population...
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sTREM2 in the prognostic evaluation of acute lung injury after cardiac surgery in infants
Previous studies have shown that TREM2 plays a protective role in acute lung injury (ALI). This prospective study aimed to investigate the role of sTREM2 as a forecasting factor for ALI in infants after pediat...
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Open AccessNLRP3 activation in macrophages promotes acute intestinal injury in neonatal necrotizing enterocolitis
Macrophages are involved in various immune inflammatory disease conditions. This study aimed to investigate the role and mechanism of macrophages in regulating acute intestinal injury in neonatal necrotizing e...
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Coinfection of SARS-CoV-2 Omicron variant and other respiratory pathogens in children
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Open AccessEfficacy of inactivated SARS-CoV-2 vaccination in pediatric hematology/oncology patients: a real-world study
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Open AccessA prospective study of the association between serum klotho and mortality among adults with rheumatoid arthritis in the USA
While it is known that klotho has negative regulatory effects in a variety of diseases such as metabolic disorders and kidney disease, the specific role of klotho in rheumatoid arthritis (RA) and its effect on...
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Open AccessRetraction Note: Shp2 positively regulates cigarette smoke-induced epithelial mesenchymal transition by mediating MMP-9 production
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Open AccessApplication of robot-assisted endoscopic technique in the treatment of patent ductus arteriosus in 106 children
The objective is to evaluate and apply the robot-assisted endoscopic surgical technique for treatment of patent ductus arteriosus (PDA) in children. Clinical data of 106 children with PDA who underwent robot-a...
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Open AccessOgt-mediated O-GlcNAcylation inhibits astrocytes activation through modulating NF-κB signaling pathway
Previous studies have shown that Ogt-mediated O-GlcNAcylation is essential for neuronal development and function. However, the function of O-GlcNAc transferase (Ogt) and O-GlcNAcylation in astrocytes remains l...
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Open AccessIntegrated bulk and single-cell RNA-sequencing reveals SPOCK2 as a novel biomarker gene in the development of congenital pulmonary airway malformation
Congenital pulmonary airway malformation (CPAM) is the most frequent pulmonary developmental malformation and the pathophysiology remains poorly understood. This study aimed to identify the characteristic gene...
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Open AccessDifferentiation between fetal and postnatal iron deficiency in altering brain substrates of cognitive control in pre-adolescence
Early iron deficiency (ID) is a common risk factor for poorer neurodevelopment, limiting children’s potential and contributing to global burden. However, it is unclear how early ID alters the substrate of brai...
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Correction to: Multigenerational birth cohort study in China: importance, necessity and beyond
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Multigenerational birth cohort study in China: importance, necessity and beyond
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Dual genetic tracing reveals a unique fibroblast subpopulation modulating cardiac fibrosis
After severe heart injury, fibroblasts are activated and proliferate excessively to form scarring, leading to decreased cardiac function and eventually heart failure. It is unknown, however, whether cardiac fi...
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Multi-omics and immune cells’ profiling of COVID-19 patients for ICU admission prediction: in silico analysis and an integrated machine learning-based approach in the framework of Predictive, Preventive, and Personalized Medicine
Intensive care unit admission (ICUA) triage has been urgent need for solving the shortage of ICU beds, during the coronavirus disease 2019 (COVID-19) surge. In silico analysis and integrated machine learning (...
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The prenatal weekly temperature exposure and neonatal congenital heart disease: a large population-based observational study in China
We aim to explore the link between maternal weekly temperature exposure and CHD in offspring and identify the relative contributions from heat and cold and from moderate and extreme atmospheric temperature. Fr...
