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Article
Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction
Cardiac fibrosis is a pathological scarring process that impairs cardiac function. N-acetyltransferase 10 (Nat10) is recently identified as the key enzyme for the N4-acetylcytidine (ac4C) modification of mRNAs...
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Article
Open AccessThe transition of eldercare responsibility and traditional filial piety concepts and its urban-rural differences in China: an age-period-cohort analysis from 2006 to 2017
With rapid urbanization, massive migration, and non-family–based eldercare involvement, Chinese concepts of eldercare responsibility and filial piety are shifting. We performed age-period-cohort (APC) analyses...
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Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Article
Kv3.1 Interaction with UBR5 Is Required for Chronic Inflammatory Pain
Chronic inflammatory pain caused by neuronal hyperactivity is a common and refractory disease. Kv3.1, a member of the Kv3 family of voltage-dependent K+ channels, is a major determinant of the ability of neurons ...
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Article
Open AccessRealization of monolayer ZrTe5 topological insulators with wide band gaps
Two-dimensional topological insulators hosting the quantum spin Hall effect have application potential in dissipationless electronics. To observe the quantum spin Hall effect at elevated temperatures, a wide b...
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Article
Nickel-catalyzed carbonylative four-component 1,4-dicarbofunctionalization of 1,3-enynes
An efficient Ni-catalyzed four-component 1,4-carbocarbonylation of 1,3-enynes with activated alkyl halides and arylboronic acids under atmospheric pressure of CO is presented. By tuning the electronic and ster...
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Article
Local discrimination of lattice states via adjacent matrix
We investigate the distinguishability of lattice states by local operations and classical communication (LOCC) in $${\mathbb {C}}^{p^{r}}\otim...
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Article
Heavy ion energy influence on multiple-cell upsets in small sensitive volumes: from standard to high energies
The 28 nm process has a high cost-performance ratio and has gradually become the standard for the field of radiation-hardened devices. However, owing to the minimum physical gate length of only 35 nm, the phys...
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Article
Stepped-up development of accelerator mass spectrometry method for the detection of 60Fe with the HI-13 tandem accelerator
The Moon provides a unique environment for investigating nearby astrophysical events such as supernovae. Lunar samples retain valuable information from these events, via detectable long-lived “fingerprint” rad...
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Article
Open AccessMild hyperthermia enhanced synergistic uric acid degradation and multiple ROS elimination for an effective acute gout therapy
Acute gouty is caused by the excessive accumulation of Monosodium Urate (MSU) crystals within various parts of the body, which leads to a deterioration of the local microenvironment. This degradation is marked...
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Article
Open AccessClinical characteristics and molecular mechanisms underlying bladder cancer in individuals with spinal cord injury: a systematic review
Patients with spinal cord injury have a relatively high risk for bladder cancer and often complicated with bladder cancer in advanced stages, and the degree of aggressiveness of malignancy is high. Most of the...
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Article
Open AccessDeep learning system for malignancy risk prediction in cystic renal lesions: a multicenter study
To develop an interactive, non-invasive artificial intelligence (AI) system for malignancy risk prediction in cystic renal lesions (CRLs).
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Article
Open AccessABO and Rhesus blood groups and multiple health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies
Numerous studies have been conducted to investigate the relationship between ABO and Rhesus (Rh) blood groups and various health outcomes. However, a comprehensive evaluation of the robustness of these associa...
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Article
Open AccessNaringin attenuates Actinobacillus pleuropneumoniae-induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway
Actinobacillus pleuropneumoniae (APP) causes porcine pleuropneumonia (PCP), which is clinically characterized by acute hemorrhagic, necrotizing pneumonia, and chronic fibrinous pneumonia. Although many measures h...
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Article
Open AccessAlleviation of migraine related pain and anxiety by inhibiting calcium-stimulating AC1-dependent CGRP in the insula of adult rats
Recent animal and clinical findings consistently highlight the critical role of calcitonin gene-related peptide (CGRP) in chronic migraine (CM) and related emotional responses. CGRP antibodies and receptor ant...
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Article
Super-stealth dicing of transparent solids with nanometric precision
Laser cutting of semiconductor wafers and transparent dielectrics has become a dominant process in manufacturing industries, encompassing a wide range of applications from display panels to microelectronic chi...
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Article
Open AccessExploring the nexus between fatigue, body composition, and muscle strength in hemodialysis patients
Fatigue is a relatively prevalent condition among hemodialysis patients, resulting in diminished health-related quality of life and decreased survival rates. The purpose of this study was to investigate the re...
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Article
MiR-210-3p enhances intermittent hypoxia-induced tumor progression via inhibition of E2F3
Intermittent hypoxia (IH) is a hallmark of obstructive sleep apnea (OSA), which is related to tumorigenesis and progression. Although micro-ribonucleic acid-210-3p (miR-210-3p) is correlated with hypoxia-induc...
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Article
Author Correction: Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway
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Article
Open AccessMini-dose methotrexate combined with methylprednisolone for the initial treatment of acute GVHD: a multicentre, randomized trial
There is an urgent unmet need for effective initial treatment for acute graft-versus-host disease (aGVHD) adding to the standard first-line therapy with corticosteroids after allogeneic haematopoietic stem cel...
