10,124 Result(s)
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Article
Studies in Acute Iron Poisoning III. The Hemodynamic Alterations in Acute Experimental Iron Poisoning
Extract: One hour after administration of a lethal dose of ferrous sulfate into the intestine, 10 dogs sustained a sharp decline in cardiac output (mean 57%), a lesser reduction of arterial blood pressure (mea...
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Article
Distribution of 3H-acetyl Growth Hormone (3H-HGH) in the Subcellular Fractions of Rat Liver
To understand the early molecular events that lead to some of the effets of growth hormone on liver, a dose of 3H-HGH (18 × 106 cpm, 60 μg) was give i.v. to hypophysectomized rats. After the injection, livers wer...
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Article
EARLY PULMONARY FUNCTION STUDIES OF INFANTS WITH BRONCHO-PULMONARY DYSPLASIA (BPD)
In 3 infants (birthweight 920, 1720 and 2030 g) with clinical and radiologic BPD, minute volume (VE), lung compliance CL (ml/cm H2O/kg), pulmonary resistance RL (cm H2O/L/sec) and blood gases were measured repeat...
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Article
FUNCTIONAL HYPOPARATHYROIDISM IN NEONATAL HYPOCALCEMIA OF INFANT OF DIABETIC MOTHER
In neonatal hypocalcemia of infants of diabetic mothers (IDM), there is associated hyperphosphatemia and calcemic responsiveness to parathyroid extract, consistent with possible hypoparathyroidism. The serum i...
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Article
DIFFERENT EFFECTS OF hGH AND bGH ON ELECTRON TRANSPORT COMPONENTS OF LIVER MITOCHONDRIA
Mitochondrial (mito) protein synthesis has been shown to be influenced by hypophysectomy (Hy) and GH treatment (JBC 248 4263:1973). Cytochromes a, a3, b, c, C1 and flavin have now been measured by difference spec...
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Article
IMMUNOELECTROPHORETIC STUDIES OF RAT SOMATOMEDIN
Serum was collected from hypophysectomized rat (HyR) 30 min. after an I.V. injection of hGH. The serum was used to prepare an antiserum (AS) in a rabbit. AS was adsorbed with lyophilized HyR serum (5 mg/ml) an...
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Article
Correlation of blood gas, lactate, and illness in newborn
We hypothesized that “true” blood lactate (LA) is an index of respiratory need superior to PaO2, PaCO2, or pH. Our thesis required a simple, rapid, sensitive LA test. We used a new automated, enzymatic 2-waveleng...
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Article
COMBINED IMMUNODEFICIENCY DISEASE CAUSED BY ADENOSINE DEAMINASE DEFICIENCY: DETECTION OF THE CARRIER STATE AND IDENTIFICATION OF A SILENT ALLELE (ADA)
Adenosine deaminase (ADA) deficiency is now recognized as a cause of one type of severe combined immunodeficiency (CID). Of major interest is the genetic transmission and the identification of heterozygotes fo...
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Article
EFFECT OF INCREASED OXYGEN-HEMOGLOBIN AFFINITY ON CARDIAC TISSUE OXYGEN UNLOADING OF LAMBS FOLLOWING INHALATION OF CARBON MONOXIDE (CO)
Previous studies in newborn lambs have shown that a decrease in whole blood oxygen affinity results in an increased coronary sinus PO2 and in an decreased cardiac output for the same oxygen consumption (VO2). The...
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Article
INTESTINAL COMPLICATIONS OF NASOJEJUNAL FEEDING
Recently Cheek and Staub reported no serious complications in 46 infants given continuous nasojejunal tube feeding. We observed serious disturbances in 4 of 13 low-birth-weight infants fed in the same manner. ...
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Article
THE EFFECT OF EXCHANGE TRANSFUSION ON PULMONARY FUNCTION OF INFANTS WITH SEVERE RESPIRATORY DISTRESS SYNDROME (RDS)
The present study was designed to investigate the mechanism of improvement of infants weighing 1200 gms. at birth or more with RDS, receiving an exchange transfusion as an adjunct to usual therapy. The present...
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Article
In Vitro Studies of Effects of Light and Riboflavin on DNA and HeLa Cells
Extract: The widespread use of phototherapy for neonatal hyperbilirubinemia has caused some concern since substances other than bilirubin may be photoactivated. The toxic properties of these photoactivated sub...
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Article
EFFECTS OF P LOADING AND INCREASED ENDOGENOUS PARA THYROID (PTH) DURING “EXCHANGE” TRANSFUSIONS ON URINARY P AND CYCLIC AMP (CAMP)
Citrate complexing of Ca during neonatal “exchange” blood transfusions is associated with stimulation of PTH; theoretically P loading occurs from partially hemolyzed or P buffered blood. During exchange transf...
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Article
EFFECTS OF MAZINDOL ON GROWTH AND GROWTH HORMONE
17 children between 5 and 15 years of age received mazindol for one year (2 mg daily). Their height was carefully evaluated by 2 physicians at 6 month intervals, and they were observed for the following year w...
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Article
HUMAN LYMPHOCYTE TRANSFORMATION FOLLOWING INHIBITION OF PURINE NUCLEOSIDE PHOSPHORYLASE
The genetic absence of purine nucleoside phosphorylase (NP) is associated with an isolated T-cell immune deficiency in humans. NP is responsible for the conversion of inosine to hypoxanthine and guanosine to g...
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Article
NEONATAL EFFECTS OF 1,25 (OH)2 VITAMIN D3 ON IONIZED Ca (iCa), Ca ABSORPTION AND PARATHYROID HORMONE(PTH)
Defects in neonatal vit D (D) metabolism theoretically might be related to neonatal hypocalcemia. 1,25 (OH)2 vitamin D3 (1,25 (OH)2D3), the final D metabolite, has been used to overcome D metabolic blocks. Thirty...
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Article
FETAL CEREBELLAR CELLS IN TISSUE CULTURE
Fetal cerebellum, obtained between gestational ages 14-22 weeks, was dispersed by mild trypsinization and centrifuged once through 2% ficoll gradient; resuspended cells were inoculated in Eagle's minimal mediu...
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Article
182 PLACENTAL IMPERMEABILITY TO PARATHORMONE (PTH) 1–125 IN THE EWE
Studies altering plasma calcium levels have demonstrated that the maternal (M) and fetal (F) parathyroid glands appear to function automonously and suggest a lack of placental permeability to PTH. To determine...
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Article
405 ZINC LEVELS IN CHILDREN WITH GROWTH RETARDATION
Concentration of zinc in hair and serum of children with short stature (familial or constitutional) was measured by atomic absorption spectrophotometry. Some of them were treated with methyltestosterone (MT), ...
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Article
242 NEONATAL HYPERMAGNESEMIA: EFFECT ON PARATHYROID HORMONE (PTH), TOTAL CALCIUM (Ca) AND IONIZED CALCIUM (iCa) LEVELS
Neoratal magnesium (Mg)-PTH interrelationships have not been examined. Pre-eclamptic mothers (n=22) receiving 3 to 40g MgSO4 during labor and their newborns (birth-72hrs) were studied. Maternal serum Mg rose from...
