Abstract
Defects in neonatal vit D (D) metabolism theoretically might be related to neonatal hypocalcemia. 1,25 (OH)2 vitamin D3 (1,25 (OH)2D3), the final D metabolite, has been used to overcome D metabolic blocks. Thirty-two prematures (≤ 37wks) were divided equally into 4 groups. Each group of 8 was pair-matched for gestation and birth asphyxia, and given daily oral lug 1,25 (OH)2 D3, 0.05ug/kg 1,25 (OH)2D3, 400 IU D2, or placebo (Pb) from 12 to 72 hrs of age. Pre-study serum PTH, (radioimmunoassay, N-terminal) was not different among the 4 groups. By 48 hrs, the lug/d 1,25 (OH)2D3 serum PTH was lower vs pretreatment, 59±9ul-Eq/ml (mean±SEM) vs 137±58ul-Eq/ml (Wilcoxon Rank t, p < .01) but was not different from the 3 other groups. At age 12 hrs, all infants had iCa < 3.5mg% (Orion SS-20, normal 3.6 to 4.5). By 48 hrs, lug/day 1,25 (OH)2D3group had significantly higher iCa, 3.6±0.1mg% vs 3.2±0.1 at 12 hrs (paired t, p<.05). Incremental iCa for lug 1,25 (OH)2D3 was greater than other 3 groups (p<.05). At 72 hrs of age, all infants had oral Ca tolerance (OCaT) 50mg/kg. Prior to OCaT, there were no differences in serum Ca among the 4 groups; the lug/day 1,25 (OH)2D3 infants had a significant rise in serum Ca at 2 and 3 hrs post-ingestion (p<.05). Peak serum Ca at 2 hrs averaged 1.2mg% vs <0.5mg% in the other 3 groups (no significant increase during OCaT). 1,25 (OH)2D3 increases intestinal Ca absorption in prematures and may be useful for the prophylaxis of neonatal hypocalcemia.
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Chan, G., Tseng, R., Chen, IW. et al. NEONATAL EFFECTS OF 1,25 (OH)2 VITAMIN D3 ON IONIZED Ca (iCa), Ca ABSORPTION AND PARATHYROID HORMONE(PTH). Pediatr Res 11, 512 (1977). https://doi.org/10.1203/00006450-197704000-00854
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DOI: https://doi.org/10.1203/00006450-197704000-00854
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