8 Result(s)
within
Priscilla D. Negraes
-
Article
Open AccessImpact of alcohol exposure on neural development and network formation in human cortical organoids
Prenatal alcohol exposure is the foremost preventable etiology of intellectual disability and leads to a collection of diagnoses known as Fetal Alcohol Spectrum Disorders (FASD). Alcohol (EtOH) impacts diverse...
-
Article
Correction: Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism
-
Article
Open AccessCortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism
Reciprocal deletion and duplication of the 16p11.2 region is the most common copy number variation (CNV) associated with autism spectrum disorders. We generated cortical organoids from skin fibroblasts of pati...
-
Article
Open AccessAltered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy
Early-onset epileptic encephalopathies are severe disorders often associated with specific genetic mutations. In this context, the CDKL5 deficiency disorder (CDD) is a neurodevelopmental condition characterize...
-
Article
Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation
Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. OPs represent a human health threat, because chronic exposure to low doses can damage th...
-
Article
Effects of ATP and NGF on Proliferation and Migration of Neural Precursor Cells
Purinergic receptors belong to the most ancient neurotransmitter system. While their relevance in neurotransmission is well characterized, it has become clear that they have many other cellular functions. Duri...
-
Article
Directed Differentiation of Neural Progenitors into Neurons Is Accompanied by Altered Expression of P2X Purinergic Receptors
Neural differentiation has been extensively studied in vitro in a model termed neurospheres, which consists of aggregates of neural progenitor cells. Previous studies suggest that they have a great potential f...
-
Article
Open AccessDNA methylation patterns in bladder cancer and washing cell sediments: a perspective for tumor recurrence detection
Epigenetic alterations are a hallmark of human cancer. In this study, we aimed to investigate whether aberrant DNA methylation of cancer-associated genes is related to urinary bladder cancer recurrence.
